1215458-51-7
2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione:hydrate
CAS: 1215458-51-7
Molecular Formula: C6H6O7
1215458-51-7 - Names and Identifiers
| Name | 2,3,5,6-tetrahydroxycyclohexa-2,5-diene-1,4-dione:hydrate |
| Synonyms | Tetrahydroxyquinone monohydrate |
| CAS | 1215458-51-7 |
1215458-51-7 - Physico-chemical Properties
| Molecular Formula | C6H6O7 |
| Molar Mass | 190.10764 |
| In vitro study | Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC 50 of 20 µM), phosphatase activity (IC 50 of 40 µM), or by MTT assay (IC 50 of 45 µM). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells. Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 µM, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure. Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 µM. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112). |
1215458-51-7 - Reference Information
| Biological activity | Tetrahydroxyquinone hydrate (Tetrahydroxy-1,4-benzoquinone hydrate), an anti-cataract agent, is a benzoquinone with redox activity. Tetrahydroxyquinone hydrate can participate in the redox cycle together with semiquinone radicals, resulting in the formation of reactive oxygen species (ROS). |
| in vitro research | Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC 50 of 20 µM), phosphatase activity (IC 50 of 40 µM), or by MTT say (IC 50 of 45 m). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells. Tetrahydroxyquinone efficiently activates caspase 3 in concentration in exit of 25 m, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure. Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 m. Tetrahydroxyquinone treatment also uses increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112). |
Last Update：2024-04-10 22:29:15
