134865-74-0

Name	4-P-PDOT
Synonyms	AH-024 4PPDOT AH-024 4P-PDOT 4-P-PDOT 4-PHENYL-2-PROPIONAMIDOTETRALIN 4-PHENYL-2- PROPIONAMIDOTETRALIN. N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-
CAS	134865-74-0

RTECS

TX1498350

Last Update：2024-01-02 23:10:35

biological activity	4-P-PDOT is a potent, selective and affinity antagonist of the melatonin receptor (MT2). The selectivity of 4-P-PDOT for MT2 was more than 300 times that of mt1. 4-P-PDOT can significantly counteract melatonin-mediated antioxidant effects (GSH/GSSG ratio, ERK phosphorylation, Nrf2 nuclear translocation, Nrf2 DNA binding activity).
Target	MT2 receptor
Cell Line:	HT-29 and HeLa cells.
Concentration:	30 min.
Incubation Time:	50 µM.
Result:	Produced a negligible effect on cell viability induced by melatonin. Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice.
Animal Model:	Klotho mutant mice treatment with Melatonin
Dosage:	0.5 mg/kg or 1.0 mg/kg
Administration:	Intravenous injection

Last Update：2024-04-09 20:49:11

Spot supply

Product Name: 4-P-PDOT Visit Supplier Webpage Request for quotation
CAS: 134865-74-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Spot supply

Product Name: 4-P-PDOT Visit Supplier Webpage Request for quotation
CAS: 134865-74-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

134865-74-0

134865-74-0 Request for Quotation