149676-40-4
Pefloxacin
CAS: 70458-92-3;149676-40-4
Molecular Formula: C18H28FN3O8S
149676-40-4 - Names and Identifiers
| Name | Pefloxacin |
| Synonyms | EU-5306 RB-1589 Pefloxacin PERFLOXACINE Perfloxacine Pefloxacin Base PEFLOXACIN METHANESULFONATE Pefloxacin Methanesulfonate Pefloxacin Mesylate Dihydrate PEFLOXACIN MESYLATE DIHYDRATE Pefloxacine Mesylate Dihydrate PEFLOXACINE MESYLATE DIHYDRATE Pefloxacine Methansulfonate Dihydrate PEFLOXACINE METHANSULFONATE DIHYDRATE Pefloxacin Methane Sulfonate Dihydrate PEFLOXACIN METHANE SULFONATE DIHYDRATE 1-ETHYL-6-FLUORO-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-QUINOLINE-3-CARBOXYLIC ACID 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| CAS | 70458-92-3 149676-40-4 |
| EINECS | 629-149-5 |
| InChI | InChI=1/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24) |
149676-40-4 - Physico-chemical Properties
| Molecular Formula | C18H28FN3O8S |
| Molar Mass | 465.49 |
| Density | 1.32g/cm3 |
| Melting Point | 271°C |
| Boling Point | 529℃ |
| Flash Point | >110°(230°F) |
| Water Solubility | Freely soluble in water |
| Solubility | H2O: soluble50mg/mL |
| Vapor Presure | 5.05E-12mmHg at 25°C |
| Appearance | neat |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.593 |
| Physical and Chemical Properties | Off-white crystals, melting point 270-272 °c (decomposition) (from dimethylformamide). Soluble in alkaline and acidic solution, slightly soluble in water. Acute toxicity LD50 mice (mg/kg):225 intravenous; 1000 oral; Rats (g/kg):1.5 intraperitoneal injection; 2.5 oral. Pefloxacin Mesylate: C17H20FN3O3? CH3SO3H? 2H2O. [149676-40-4]. White to yellowish crystalline powder, a few odorless, slightly bitter taste. Soluble in water, ethanol-soluble, a few insoluble in ether. |
| Use | The third generation of quinolone antibacterial drugs, has a broad spectrum of antibacterial effect, the antibacterial spectrum and antibacterial activity and norfloxacin similar. The bacteria are inhibited or killed by interfering with the replication of DNA and the synthesis of bacterial proteins. It has a strong antibacterial effect on Staphylococcus aureus, and has a very strong antibacterial effect on a variety of gram-negative bacteria and strains resistant to ampicillin and TMP cephalosporin V, it is as effective against intestinal bacteria as third-generation cephalosporins, but less effective against anaerobes, tubercle bacilli, and Clostridia. It is not easy to produce drug resistance. For sepsis, bacterial meningitis, respiratory tract, urinary tract, kidney, liver and gallbladder, gynecological diseases, bone and joint infections. |
149676-40-4 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | VB2002200 |
| HS Code | 29335990 |
149676-40-4 - Reference
| Reference Show more | 1. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 |
149676-40-4 - Nature
Open Data Verified Data
- white crystals. Melting point 270 to 272 ° C. (decomposition) (obtained from dimethylformamide). Soluble in alkaline and acidic solution, slightly soluble in water.
- pefloxacin mesylate: white to yellowish crystalline powder, almost odorless, with slightly bitter taste. Soluble in water, slightly soluble in ethanol, almost not in ether.
Last Update：2024-01-02 23:10:35
149676-40-4 - Preparation Method
Open Data Verified Data
with norfloxacin as raw material, the product was obtained by methylation.
Last Update：2022-01-01 09:08:55
149676-40-4 - Use
Open Data Verified Data
developed by the French company longpaoranck (Rhone-poukenc), it was launched in France in 1984. The third generation of quinolone antibacterial drugs, has a broad spectrum of antibacterial effect, the antibacterial spectrum and antibacterial activity and norfloxacin similar. By interfering with the replication of DNA and the synthesis of bacterial proteins, the bacteria are inhibited or killed. It has a strong antibacterial effect on Staphylococcus aureus, and has a very strong antibacterial effect on a variety of gram-negative bacteria and strains resistant to ampicillin, TMP and cephalosporin V, it is effective against intestinal bacteria and third-generation cephalosporins, but less effective against anaerobes, tubercle bacilli, and Clostridia. It is not easy to produce drug resistance. For sepsis, bacterial meningitis, respiratory tract, urinary tract, kidney, liver and gallbladder, gynecological diseases, bone and joint infections.
Last Update：2022-01-01 09:08:56
149676-40-4 - Safety
Open Data Verified Data
mouse LDsa (mg/kg):225 intravenous; 1000 oral; Rat LDso (g/kg):1.5 intraperitoneal; 2.5 oral.
Last Update：2022-01-01 09:08:56
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Multiple Specifications
Product Name: Pefloxacin Visit Supplier Webpage Request for quotationCAS: 70458-92-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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