Name | 2,3,5-trichloropyridine |
Synonyms | Trichloropyridine 5-Trichloropyridine 3,5,6-Trichloropyridine 2,3,5-trichloro-pyridin 2,3,5-trichloropyridine 2,3,5-TRICHLOROPYRIDINE Pyridine, 2,3,5-trichloro- 2,3,5 - cross-linked with pyridine |
CAS | 16063-70-0 |
EINECS | 407-270-2 |
InChI | InChI=1/C5H2Cl3N/c6-3-1-4(7)5(8)9-2-3/h1-2H |
Molecular Formula | C5H2Cl3N |
Molar Mass | 182.44 |
Density | 1.539±0.06 g/cm3(Predicted) |
Melting Point | 46-50 °C (lit.) |
Boling Point | 219 °C (lit.) |
Flash Point | >230°F |
Water Solubility | Slightly soluble in water. |
Vapor Presure | 0.213mmHg at 25°C |
Appearance | White crystal |
Color | Off-white to pale yellow |
BRN | 119384 |
pKa | -2.92±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.572 |
MDL | MFCD00043007 |
Hazard Symbols | Xi - Irritant |
Risk Codes | R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 2 |
RTECS | UU0525000 |
HS Code | 29333990 |
Hazard Note | Irritant |
introduction | 2,3, 5-trichloropyridine is a light yellow solid and an important fine chemical intermediate. 2,3,5-trichloropyridine reacts with alkali metal hydroxide to prepare 3,5-dichloro-2-pyridine phenol, which is an important raw material for the synthesis of insecticidal mites and herbicide oxaloether. 2,3, 5-trichloropyridine can also be further fluorinated to synthesize 2, 3-difluoro-5-chloropyridine, which is the basic raw material for the synthesis of herbicide alkynurate. |
preparation | 60g of methanol was added to a 1000mL four-mouth flask, 100g 2,3,5,6-tetrachloropyridine and 31.7g of hydrazine hydrate were added, the temperature was raised to 60-65 ℃, the heat preservation reaction was carried out for about 2 hours, the reaction was finished, the temperature was lowered to 0-5 ℃, the temperature was lowered to 1 hour, the solid was filtered, and the solid was 2,3, 5-trichlor6-hydrazinyl pyridine hydrate was dried to obtain 101.6g of white solid with 96% yield and 98.5% content. Add 100g 2,3,5-trichloro 6-hydrazinyl pyridine hydrate, 50g of 5% sodium hydroxide aqueous solution to 1000ml of four-mouth bottle, raise the temperature to 70-75 ℃, add 387.6g of 10% sodium hypochlorite aqueous solution dropwise, keep the temperature at 70-75 ℃, react for 1 hour, end the reaction, cool to 5-10 ℃, stir for 1 hour, filter to obtain 2,3, the crude 5-trichloropyridine is distilled under reduced pressure to obtain the product, which is a light yellow solid with a yield of 95% and a content of 98%. |