17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE
17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
CAS: 10106-41-9
Molecular Formula: C24H30O5
17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE - Names and Identifiers
17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE - Physico-chemical Properties
| Molecular Formula | C24H30O5 |
| Molar Mass | 398.49 |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Melting Point | 210-213 °C |
| Boling Point | 560.0±50.0 °C(Predicted) |
| pKa | 12.48±0.70(Predicted) |
| Physical and Chemical Properties | Chemical properties crystallization. Melting point 208 ℃. |
| Use | Use an intermediate of dexamethasone acetate. |
17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE - Production method
You can use 3 β-hydroxygestrol -5,16-diene -20-one -3-acetate (ie gestational dienolone acetate) via (16-position double bond nitrosomethyl urea) Addition and elimination to generate 3 β-hydroxy -16 β-methyl gestrol -5,16-diene -20-one, then [16(17)-position] epoxidation, acetylation and epoxy ring opening (formation of 17 α-hydroxyl and 15-position double bond), and then (15-position double bond) catalytic hydrogenation, hydrolysis (removal of 3-position acetyl group), (3-position hydroxyl group) oxidation (double bond to 4-position), (21-position) iodization, (21-position iodine with acetoxy group) replacement, Biological oxidation (introduction of 11-hydroxyl group)(11-hydroxyl group) sulfonylation and elimination [formation of 9(11)-double bond] to obtain this product.
Last Update：2024-04-10 22:29:15
Supplier List
Multiple SpecificationsSpot supply
Product Name: Dexamethasone Acetate Impurity 8(Dexamethasone Acetate EP Impurity H) Visit Supplier Webpage Request for quotationCAS: 10106-41-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
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Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Dexamethasone Acetate Impurity 8(Dexamethasone Acetate EP Impurity H) Visit Supplier Webpage Request for quotationCAS: 10106-41-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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