1780791-11-8 - Names and Identifiers
1780791-11-8 - Introduction
2-(3,4-dimethylphenyl)-2,2-difluoroethan-1-ol is an organic compound with the chemical formula C10H13F2OH. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in organic solvents such as alcohols and ethers
-Melting point:-32 ℃
-Boiling point: 172-174 ℃
-Density: 0.984 g/mL
Use:
- 2-(3,4-dimethylphenyl)-2,2-difluoroethan-1-ol can be used as a reagent in organic synthesis, especially in pharmaceutical synthesis. It has a certain chiral activity and can be used as a catalyst or ligand for asymmetric synthesis.
-It can also be used in the production of coatings, plastics and adhesives.
Method:
The preparation of 2-(3,4-dimethylphenyl)-2,2-difluoroethan-1-ol is generally carried out by the following steps:
1.3,4-dimethylbenzaldehyde and boric acid are added to a reaction vessel and heated to react to generate 3,4-dimethylcyclopentanone.
2. The resulting 3,4-dimethylcyclopentanone is reacted with difluoroacetyl chloride in the presence of a base to give 2-(3,4-dimethylphenyl)-2,2-difluoroacetoacetic acid.
3.2-(3,4-dimethylphenyl)-2,2-difluoroacetoacetic acid was reacted with sodium hydroxide to give the final product 2-(3,4-dimethylphenyl)-2,2-difluoroethan-1-ol.
Safety Information:
2-(3,4-dimethylphenyl)-2,2-difluoroethan-1-ol should follow the general laboratory practices and safety guidelines. It is an irritating compound and may have an irritating effect on the eyes, skin and respiratory tract. Appropriate personal protective equipment such as gloves and safety glasses should be worn during operation. If there is inhalation or contact, it should be cleaned in time.
Last Update：2024-04-09 02:00:51