1H-1,2,4-Triazole-3-methanol, 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)-
Lavoltidine
CAS: 76956-02-0
Molecular Formula: C19H29N5O2
1H-1,2,4-Triazole-3-methanol, 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)- - Names and Identifiers
1H-1,2,4-Triazole-3-methanol, 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)- - Physico-chemical Properties
| Molecular Formula | C19H29N5O2 |
| Molar Mass | 359.471 |
1H-1,2,4-Triazole-3-methanol, 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)- - References
| Biological activity | Lavoltidine (Loxtidine) is an orally active, irreversible and highly effective histamine H2 receptor antagonist. Lavoltidine strongly inhibited gastric acid secretion and induced hypergastrinemia. |
| Animal Model: | Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis |
| Dosage: | 0.5 g/L |
| Administration: | Orally (drinking water); changed weekly; for 3 months |
| Result: | Showed partial suppression of both gastric acid secretion and progression to neoplasia. |
Last Update：2024-04-09 20:49:11
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