1H-Indazole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester
methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate
CAS: 877773-17-6
Molecular Formula: C10H7F3N2O2
1H-Indazole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester - Names and Identifiers
| Name | methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate |
| Synonyms | methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate 6-TRIFLUOROMETHYL-1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER 1H-Indazole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester 1H-Indazole-3-carboxylic acid, 6-(trifluoroMethyl)-, Methyl ester |
| CAS | 877773-17-6 |
| InChI | InChI=1S/C10H7F3N2O2/c1-17-9(16)8-6-3-2-5(10(11,12)13)4-7(6)14-15-8/h2-4H,1H3,(H,14,15) |
1H-Indazole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester - Physico-chemical Properties
| Molecular Formula | C10H7F3N2O2 |
| Molar Mass | 244.17 |
1H-Indazole-3-carboxylic acid, 6-(trifluoromethyl)-, methyl ester - Introduction
Methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate (methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate) is an organic compound containing a trifluoromethyl group and an indazolyl group in its chemical structure. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: A colorless to light yellow solid
-Molecular formula: C11H7F3N2O2
-Molecular weight: 250.18g/mol
-Melting point: 110-113°C
-Boiling point: 338°C (decomposition)
-Solubility: Soluble in some organic solvents such as chloroform, dimethyl sulfoxide and dichloromethane.
Use:
- methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate is a potential drug intermediate that can be used for research and development of drugs.
-The compound can also be used as a reagent in organic synthesis reactions, especially as a carbon-hydrogen bond activator and a catalyst for nucleophilic reactions.
Preparation Method:
- methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate is generally synthesized by synthetic routes. One common method of preparation is by reacting methyl pyridine-3-carboxylate with trifluoromethyl isocyanate to give an intermediate, followed by hydrogenation reduction and carboxylation to give the final product.
Safety Information:
-Due to the lack of specific experimental data, there is less information about the toxicity and danger of this compound. However, as an organic compound, standard laboratory safety practices should generally be followed, such as wearing appropriate protective equipment (such as gloves and glasses), avoiding inhalation and skin contact, and handling in a well-ventilated environment.
Nature:
-Appearance: A colorless to light yellow solid
-Molecular formula: C11H7F3N2O2
-Molecular weight: 250.18g/mol
-Melting point: 110-113°C
-Boiling point: 338°C (decomposition)
-Solubility: Soluble in some organic solvents such as chloroform, dimethyl sulfoxide and dichloromethane.
Use:
- methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate is a potential drug intermediate that can be used for research and development of drugs.
-The compound can also be used as a reagent in organic synthesis reactions, especially as a carbon-hydrogen bond activator and a catalyst for nucleophilic reactions.
Preparation Method:
- methyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate is generally synthesized by synthetic routes. One common method of preparation is by reacting methyl pyridine-3-carboxylate with trifluoromethyl isocyanate to give an intermediate, followed by hydrogenation reduction and carboxylation to give the final product.
Safety Information:
-Due to the lack of specific experimental data, there is less information about the toxicity and danger of this compound. However, as an organic compound, standard laboratory safety practices should generally be followed, such as wearing appropriate protective equipment (such as gloves and glasses), avoiding inhalation and skin contact, and handling in a well-ventilated environment.
Last Update：2024-04-09 20:45:29
