1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
PRT4165
CAS: 31083-55-3
Molecular Formula: C15H9NO2
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- - Names and Identifiers
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- - Physico-chemical Properties
| Molecular Formula | C15H9NO2 |
| Molar Mass | 235.24 |
| Density | 1.1757 (rough estimate) |
| Boling Point | 377.63°C (rough estimate) |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.6231 (estimate) |
| In vitro study | PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation. In vitro E3 ubiquitin ligase activity assays reveal that PRT4165 inhibits both RNF2 and RING 1A, but not RNF8 nor RNF168. In the presence of PRT4165, H2A ubiquitylation can be completely inhibited regardless of whether RING1 or RNF2 contributes the E3 ubiquitin ligase activity. Treatment of cells for 60 min with 50 μM PRT4165 results in a dramatic reduction in total ubiquitylated histone H2A. It is also found that longer exposure of the cells with the PRT4165 (30 and 60 min) leads to increased levels of γ-H2AX in unirradiated cells. PRT4165 inhibits double-strand break (DSB) repair at the 8-h time point compare with mock treated cells. Cells treated with increasing concentrations of PRT4165 show increasing numbers of cells in G 2 /M. |
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- - Risk and Safety
| WGK Germany | 3 |
| RTECS | NK6710000 |
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.251 ml | 21.255 ml | 42.51 ml |
| 5 mM | 0.85 ml | 4.251 ml | 8.502 ml |
| 10 mM | 0.425 ml | 2.126 ml | 4.251 ml |
| 5 mM | 0.085 ml | 0.425 ml | 0.85 ml |
Last Update：2024-01-02 23:10:35
1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)- - Reference Information
| biological activity | PRT4165 is a potent inhibitor of prc1-mediated H2A ubiquitination. |
| Target | PRC1 |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: PRT4165 Visit Supplier Webpage Request for quotationCAS: 31083-55-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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