| Overview | cycloindanoic acid, also known as chlorocycloindanoic acid, caltaric acid, chemical name: 6-chloro-5-cycloethyl-1-indanecarboxylic acid is the first analgesic drug listed abroad in 1981. It has antipyretic, analgesic, anti-inflammatory, antidiuretic, gastrointestinal ulcer and other pharmacological effects, for the deformation of joint disease, shoulder periarthritis, neck, shoulder and wrist syndrome, back pain and other patients with analgesic, anti-inflammatory, antipyretic cancer patients. |
| pharmacodynamics | animal experiments show that the product with diclofenac sodium, indomethacin compared to equal or more excellent anti-inflammatory and analgesic effect, antipyretic effect is significantly better. Inhibition of prostaglandin biosynthesis is stronger than indomethacin. |
| pharmacokinetics | after oral administration of 15mg,8h later, the maximum plasma concentration was 1.17 μg/ml, after 24h, it decreased by half and was considered to be persistent. Plasma metabolites were not detected within 24h 32% of this product and its metabolites from urinary excretion. |
| Usage | used for analgesia and anti-inflammation of patients with deformed joint disease, shoulder periarthritis, neck, shoulder and wrist syndrome, low back pain, etc, antipyretic in patients with malignant tumors. The overview, physicochemical properties, pharmacodynamics, pharmacokinetics, and uses of the cyclochlorindonic acid are compiled by Ding Hong. (2015-11-16) |
| adverse reaction | ① edema, which should be discontinued and diuretics (furosemide, etc. ② kidney: the drug should be discontinued if blood urea nitrogen and proteinuria increase occasionally. ③ liver: the drug should be discontinued if SGOT and SGPT increase occasionally. ④ blood: occasionally red, white blood cell count decreased and epistaxis should be discontinued. (5) the drug should be discontinued in case of occasional rash and pruritus. The digestive organs: occasional peptic ulcer, gastrointestinal bleeding, rare gastric perforation, etc., should be discontinued. Occasional stomach and abdomen discomfort, Abdominal Pain, belching, Vomit, loss of appetite, stomach abdominal distension, heartburn, constipation, Diarrhea, soft stool, stomatitis, chapped tongue, etc. The mental nervous system was occasionally drowsy. O Other: occasional burnout, tinnitus, palpitations, etc. |
| precautions | ① patients with peptic ulcer, kidney disease, severe liver disease, severe blood abnormalities, allergic to this product and the use of aspirin has caused asthma patients. Contraindicated in pregnant and lactating women. (2) caution should be used in patients with a history of peptic ulcer, kidney disease, liver disease, blood abnormalities or allergies and bronchial asthma. Elderly and pediatric medication should pay special attention to the occurrence of side effects, limit the necessary minimum dose. (3) This product is easy to cause edema, should pay full attention to the use of long-term use of urine, blood, liver function, etc., such as abnormal, should be reduced, drug withdrawal. This product should be used before the digestive tract inquiry and X-ray examination. (4) to avoid with other anti-inflammatory analgesics. |
