1H-Indole, 2-bromo- - Names and Identifiers
1H-Indole, 2-bromo- - Physico-chemical Properties
Molecular Formula | C8H6BrN
|
Molar Mass | 196.04 |
Density | 1.660 |
Boling Point | 316.9±15.0 °C(Predicted) |
Flash Point | 145.5°C |
Vapor Presure | 0.000738mmHg at 25°C |
pKa | 15.34±0.30(Predicted) |
Storage Condition | -20℃ |
Refractive Index | 1.711 |
1H-Indole, 2-bromo- - Introduction
2-Bromoindole is an organic compound with the chemical formula C8H6BrN. The following is a description of the properties, uses, preparation and safety information of 2-bromoindole:
Nature:
-Appearance: 2-Bromoindole is white to light yellow crystal or crystalline powder.
-Solubility: It dissolves in organic solvents such as ethanol and dimethyl sulfoxide, but has low solubility in water.
-Melting point: The melting point of 2-bromoindole is approximately 120-124 degrees Celsius.
-Chemical properties: This compound is a weak base that can be oxidized by strong bases and oxidants such as sodium hydroxide or silver chloride.
Use:
-Chemical research: 2-bromoindole is commonly used as an intermediate in organic synthesis reactions, such as as a raw material for the synthesis of indole compounds, or for the synthesis of other biologically active molecules.
-Drug research: Because of its indole ring in its structure, 2-bromoindole has potential drug activity. Therefore, it is also used in the field of drug research.
Preparation Method:
2-Bromoindole is usually prepared by the following steps:
1. Indole is reacted with hydrogen bromide or bromoindole compound is used to react with nucleophile to introduce bromine atom.
2. Then, after appropriate treatment and separation steps, 2-bromoindole is obtained.
Safety Information:
-2-Bromoindole may be irritating to the skin, eyes and respiratory tract, so appropriate personal protective equipment such as gloves, goggles and masks should be worn during operation.
-When using or storing 2-bromoindole, avoid contact with strong oxidants and strong bases to avoid dangerous reactions.
-If ingested or inhaled, seek medical help immediately and provide the package or label to your doctor.
-When storing, keep 2-bromoindole in a dry, well-ventilated place, away from high temperature and fire.
Last Update:2024-04-09 20:49:11