1H-Indole-1-carboxylic acid, 5-hydroxy-,1,1-diMethylethyl ester
N-Boc-5-Hydroxyindole
CAS: 434958-85-7
Molecular Formula: C13H15NO3
1H-Indole-1-carboxylic acid, 5-hydroxy-,1,1-diMethylethyl ester - Names and Identifiers
| Name | N-Boc-5-Hydroxyindole |
| Synonyms | 5-AMINOPHTHALIC ACID 1-BOC-5-HYDROXYINDOLE N-BOC-5-HYDROXYINDOLE 1-Boc-5-hydroxyindole N-Boc-5-Hydroxyindole 5-hydroxy-1-indolecarboxylate 5-hydroxy-1H-indole-1-carboxylate tert-butyl 5-hydroxyindole-1-carboxylate tert-butyl 5-hydroxy-1H-indole-1-carboxylate 1H-Indole-1-carboxylicacid, 5-hydroxy-, 1,1-dimethylethylester 1H-Indole-1-carboxylic acid, 5-hydroxy-,1,1-diMethylethyl ester |
| CAS | 434958-85-7 |
| InChI | InChI=1/C13H15NO3/c1-13(2,3)17-12(16)14-7-6-9-8-10(15)4-5-11(9)14/h4-8,15H,1-3H3 |
1H-Indole-1-carboxylic acid, 5-hydroxy-,1,1-diMethylethyl ester - Physico-chemical Properties
| Molecular Formula | C13H15NO3 |
| Molar Mass | 233.26 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| Boling Point | 374.5±34.0 °C(Predicted) |
| Flash Point | 180.3°C |
| Vapor Presure | 3.87E-06mmHg at 25°C |
| pKa | 9.55±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.558 |
1H-Indole-1-carboxylic acid, 5-hydroxy-,1,1-diMethylethyl ester - Introduction
N-Boc-5-Hydroxyindole(N-Boc-5-Hydroxyindole) is an organic compound whose chemical formula is C12H13NO3. The following is a description of some properties, uses, preparation and safety information about the compound:
Nature:
N-Boc-5-Hydroxyindole is a colorless or yellowish crystal with a distinctive vanilla odor. It is soluble in organic solvents such as methanol, ethanol and dichloromethane.
Use:
N-Boc-5-Hydroxyindole is mainly used for hydroxylation reaction in organic synthesis and synthesis of indole compounds. It is an important intermediate that can be used to synthesize a variety of drugs, pesticides and heterocyclic compounds. In addition, it can also be used as biological markers, optical materials and organic electronic materials.
Preparation Method:
The preparation method of N-Boc-5-Hydroxyindole is mainly obtained by reacting 5-hydroxyindole with Boc anhydride (t-butoxycarbonyl). Specific steps are generally as follows:
1. In an anhydrous organic solvent, 5-hydroxyindole is reacted with Boc anhydride in the presence of an imino catalyst.
2. After completion of the reaction, the mixture was cooled and an acidic aqueous solution was added to acidify the product.
3. The formed crystalline product is collected and appropriately purified and dried.
Safety Information:
N-Boc-5-Hydroxyindole has less impact on the human body under general conditions. However, it is still a chemical with a certain degree of danger. During handling and use, correct laboratory safety procedures should be followed, such as wearing protective gloves, glasses and laboratory coats, avoiding inhalation, contact with skin and ingestion. In addition, it should be stored in a dry, cool and well-ventilated place, away from fire and oxidizing agents. In case of accidental spills or poisoning, seek medical assistance immediately. If necessary, refer to the relevant Chemical Safety Data Sheet (MSDS) for more detailed safety information.
Nature:
N-Boc-5-Hydroxyindole is a colorless or yellowish crystal with a distinctive vanilla odor. It is soluble in organic solvents such as methanol, ethanol and dichloromethane.
Use:
N-Boc-5-Hydroxyindole is mainly used for hydroxylation reaction in organic synthesis and synthesis of indole compounds. It is an important intermediate that can be used to synthesize a variety of drugs, pesticides and heterocyclic compounds. In addition, it can also be used as biological markers, optical materials and organic electronic materials.
Preparation Method:
The preparation method of N-Boc-5-Hydroxyindole is mainly obtained by reacting 5-hydroxyindole with Boc anhydride (t-butoxycarbonyl). Specific steps are generally as follows:
1. In an anhydrous organic solvent, 5-hydroxyindole is reacted with Boc anhydride in the presence of an imino catalyst.
2. After completion of the reaction, the mixture was cooled and an acidic aqueous solution was added to acidify the product.
3. The formed crystalline product is collected and appropriately purified and dried.
Safety Information:
N-Boc-5-Hydroxyindole has less impact on the human body under general conditions. However, it is still a chemical with a certain degree of danger. During handling and use, correct laboratory safety procedures should be followed, such as wearing protective gloves, glasses and laboratory coats, avoiding inhalation, contact with skin and ingestion. In addition, it should be stored in a dry, cool and well-ventilated place, away from fire and oxidizing agents. In case of accidental spills or poisoning, seek medical assistance immediately. If necessary, refer to the relevant Chemical Safety Data Sheet (MSDS) for more detailed safety information.
Last Update：2024-04-09 20:52:54
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