1H-indazol-4-yl-4-boronic acid
1H-indazol-4-ylboronic acid
CAS: 1023595-17-6
Molecular Formula: C7H7BN2O2
1H-indazol-4-yl-4-boronic acid - Names and Identifiers
| Name | 1H-indazol-4-ylboronic acid |
| Synonyms | 4-Borono-1H-indazole Indazole-4-boronic acid 1H-indazole-4-boronic acid 1H-Indazole-4-boronic acid 1H-indazol-4-ylboronic acid 1H-indazole-4-boronic aci... 1H-indazol-4-yl-4-boronic acid 1H-indazol-4-yl-4-ylboronic acid Boronic acid, B-1H-indazol-4-yl- Indazole-4-boronic acid, hydrochloride Indazole-4-Boronic Acid, Hydrochloride |
| CAS | 1023595-17-6 |
| InChI | InChI=1S/C7H7BN2O2/c11-8(12)6-2-1-3-7-5(6)4-9-10-7/h1-4,11-12H,(H,9,10) |
1H-indazol-4-yl-4-boronic acid - Physico-chemical Properties
| Molecular Formula | C7H7BN2O2 |
| Molar Mass | 161.96 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 173-177°C |
| Boling Point | 457.0±37.0 °C(Predicted) |
| Flash Point | 230.193 °C |
| Appearance | Crystalline Powder |
| Color | White to tan |
| pKa | 7.92±0.30(Predicted) |
| Storage Condition | 2-8°C |
1H-indazol-4-yl-4-boronic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| HS Code | 29339900 |
1H-indazol-4-yl-4-boronic acid - Introduction
1H-indazole-4-boronic acid is an organic compound with the chemical formula C3H4BN3O2.
Nature:
1H-Indazole-4-boronic acid is a white crystalline solid, soluble in water and organic solvents. It is a weak acid capable of forming salts with bases. Its pKa is about 4.5, and the lower the pH, the better its solubility.
Use:
1H-indazole-4-boronic acid has a variety of applications in chemical research and synthesis. It is often used as a substrate or intermediate for the preparation of other organic compounds. In addition, it can also be used as a precursor for heterocyclic ligands, catalysts or fluorescent dyes.
Preparation Method:
In general, 1H-indazole-4-boronic acid can be synthesized by reacting indazole with boronic acid or boronic acid ester. The reaction is carried out under acidic conditions, and the reaction temperature is generally between room temperature and the boiling point of the reactants.
Safety Information:
1H-indazole-4-boronic acid is generally considered to be less harmful to humans and the environment. However, as a chemical substance, it is still necessary to pay attention to safe operation. When handling, wear appropriate protective equipment to avoid contact with skin, eyes and respiratory tract. Avoid inhaling dust or vapors. After use, the waste liquid should be properly treated to avoid pollution to the environment. When stored, it should be kept away from fire and oxidizer to avoid fire or explosion. Detailed safety operation information should refer to the relevant safety data sheet.
Nature:
1H-Indazole-4-boronic acid is a white crystalline solid, soluble in water and organic solvents. It is a weak acid capable of forming salts with bases. Its pKa is about 4.5, and the lower the pH, the better its solubility.
Use:
1H-indazole-4-boronic acid has a variety of applications in chemical research and synthesis. It is often used as a substrate or intermediate for the preparation of other organic compounds. In addition, it can also be used as a precursor for heterocyclic ligands, catalysts or fluorescent dyes.
Preparation Method:
In general, 1H-indazole-4-boronic acid can be synthesized by reacting indazole with boronic acid or boronic acid ester. The reaction is carried out under acidic conditions, and the reaction temperature is generally between room temperature and the boiling point of the reactants.
Safety Information:
1H-indazole-4-boronic acid is generally considered to be less harmful to humans and the environment. However, as a chemical substance, it is still necessary to pay attention to safe operation. When handling, wear appropriate protective equipment to avoid contact with skin, eyes and respiratory tract. Avoid inhaling dust or vapors. After use, the waste liquid should be properly treated to avoid pollution to the environment. When stored, it should be kept away from fire and oxidizer to avoid fire or explosion. Detailed safety operation information should refer to the relevant safety data sheet.
Last Update：2024-04-10 22:29:15
