The preparation method is to dissolve (±) cis-chrysanthemum acid and the splitting agent quinine in ethanol solution, place the crystallization under warm heat, and the obtained crystal is recrystallized with ethanol, then acidified with hydrochloric acid, and extracted with chloroform, Drying and desolution to obtain the product. (-)α-methylbenzylamine can also be used to obtain 1R-cis-chrysanthemum acid. In addition, ()α-p-methylbenzylaniline (PTE for short) can be used as a resolution agent to obtain 1R-cis-chrysanthemum acid.
In addition, cis-chrysanthemum can be obtained from 1S, 3S-trans chrysanthemum acid through epimerism. The process is: add methanol and water to the dilute solution of 1S, 3S-trans-chrysanthemum acid to hydrate it and generate esters, that is, the butene group in chrysanthemum acid becomes a stable saturated bond containing hydroxyl group and becomes 2-Hydroxy -2-methyl propane group. Then in the presence of potassium tert-butoxide, C3 atom selective isomerization is carried out to obtain dihydrochrysanthemum lactone, and 1R-cis chrysanthemum acid is obtained by opening the ring.