2',3',5'-Tri-O-acetyluridine
2,3,5-triacetyluridine
CAS: 4105-38-8
Molecular Formula: C15H18N2O9
2',3',5'-Tri-O-acetyluridine - Names and Identifiers
| Name | 2,3,5-triacetyluridine |
| Synonyms | RG 2133 Vistonuridine Uridine triacetate Tri-O-acetyl uridine 2,3,5-triacetyluridine 2',3',5'-Tri-O-acetyl-rU 2',3',5'-Triacetyluridine 2',3',5'-tri-O-acetyluridine 2',3',5'-Tri-O-acetyluridine 1-(2,3,5-tri-O-acetylpentofuranosyl)pyrimidine-2,4(1H,3H)-dione 1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyrimid (2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate 1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione |
| CAS | 4105-38-8 |
| EINECS | 223-881-5 |
| InChI | InChI=1/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22) |
| InChIKey | AUFUWRKPQLGTGF-QRMSVCKNSA-N |
2',3',5'-Tri-O-acetyluridine - Physico-chemical Properties
| Molecular Formula | C15H18N2O9 |
| Molar Mass | 370.31 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Melting Point | 127.0 to 131.0 °C |
| Solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly) |
| Appearance | Solid |
| Color | Off-White |
| pKa | 9.39±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.552 |
| MDL | MFCD00023795 |
2',3',5'-Tri-O-acetyluridine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29349990 |
2',3',5'-Tri-O-acetyluridine - Reference Information
| uridine triacetate | on September 4, 2015, the U.S. FDA approved the listing of Wellstat's new molecular entity drug uridine triacetate (Uridine Triacetate) oral granules under the trade name of Xuriden through priority approval channels. It is used for the treatment of congenital hyperuricemia, a rare disease of hereditary whey aciduria, awarded to orphan drugs and priority review. Uridine triacetate is a substitute for uridine. Uridine can promote the conversion of orotic acid into uridine acid in the body, thereby avoiding a large amount of orotic acid in the blood and urine. |
| biological activity | Uridine triacetate (Vistonuridine, PN401) is an oral active prodrug of the natural product nucleoside uridine. It is used to treat hereditary orosic aciduria or in emergency treatment such as fluorouracil, capecitabine overdose or toxicity. |
Last Update：2024-04-10 22:29:15
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