2'-Fluoroacetophenone
2'-Fluoroacetophenone
CAS: 445-27-2
Molecular Formula: C8H7FO
2'-Fluoroacetophenone - Names and Identifiers
| Name | 2'-Fluoroacetophenone |
| Synonyms | Fluoroacetophenone1 2-FLUOROACETOPHENONE O-FLUOROACETOPHENONE 2'-FLUOROACETOPHENONE 2'-Fluoroacetophenone LABOTEST-BB LT01148268 1-(2-FLUOROPHENYL)ETHANONE Ethanone, 1-(2-fluorophenyl)- Fluoroacetophenonemincolorlessliq |
| CAS | 445-27-2 |
| EINECS | 207-156-0 |
| InChI | InChI=1/C7H6FNO/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H2,9,10) |
| InChIKey | QMATYTFXDIWACW-UHFFFAOYSA-N |
2'-Fluoroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H7FO |
| Molar Mass | 138.14 |
| Density | 1.238g/cm3 |
| Melting Point | 26-27C |
| Boling Point | 238.4°C at 760 mmHg |
| Flash Point | 98°C |
| Vapor Presure | 0.0426mmHg at 25°C |
| Appearance | Form Liquid, color Clear colorless to yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.538 |
| Physical and Chemical Properties | Physical and chemical properties 2 '-fluoroacetophenone is colorless or yellowish, light green oily liquid or flake crystals at room temperature, insoluble in water, soluble in most organic solvents such as ethanol and ether. Flammable, releasing irritating toxic gases. Toxic chemicals, but lack of toxicity data, can refer to the toxicity of fluorobenzene and acetophenone, its toxicity is similar to benzene. The chemical reaction performance of o-fluoroacetophenone is similar to that of benzene, which can undergo substitution, addition, condensation, oxidation, reduction and other reactions. It can be condensed with ethyl formate under alkaline conditions. |
| Use | The main use of 2 '-fluoroacetophenone is organic intermediates, used in the synthesis of new drugs, such as bronchodilators, can also be used in the synthesis of dyes and other fine chemicals. |
2'-Fluoroacetophenone - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2810 |
| WGK Germany | 3 |
| HS Code | 29147090 |
| Hazard Class | IRRITANT |
| Packing Group | III |
2'-Fluoroacetophenone - Upstream Downstream Industry
| Downstream Products | 5-Fluoro-1-tetralone 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile |
2'-Fluoroacetophenone - Nature
| Solubility | Soluble in Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate and Methanol. |
| Specific gravity | 1.121 |
| BRN | 2041344 |
| NIST chemical information | o-Fluoroacetophenone(445-27-2) |
Last Update：2024-04-09 21:11:58
2'-Fluoroacetophenone - Uses and synthesis methods
Introduction
2 '-fluoroacetophenone is a pharmaceutical intermediate that can be used as a starting material for the synthesis of Vonorazan fumarate. Vonorazan Fumarate, English name: Vonoprazan Fumarate, trade name: Takecab, is a potassium competitive acid blocker developed by Takeda Pharmaceutical Company of Japan, used to treat erosive esophagitis, gastric ulcer, and twelve fingers Intestinal ulcer, Helicobacter pylori eradication, etc. It was listed in Japan on December 26, 2014.
method of synthesis
There are two methods for synthesizing o-fluoroacetophenone. One is the reaction of α-bromoacetophenone with hydrogen fluoride in the presence of pyridine, and the other is the reaction of fluoroacetyl chloride with benzene in the presence of aluminum trichloride. o-fluoroacetophenone can also be obtained, and then the product is refined and purified.
Last Update：2024-04-09 22:09:11
Supplier List
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: TAK438 Impurity 97 Visit Supplier Webpage Request for quotationCAS: 445-27-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: 2'-Fluoroacetophenone Request for quotation
CAS: 445-27-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 445-27-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Fluoroacetophenone1 Request for quotation
CAS: 445-27-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 445-27-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: TAK438 Impurity 97 Visit Supplier Webpage Request for quotationCAS: 445-27-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: 2'-Fluoroacetophenone Request for quotationCAS: 445-27-2
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: 2'-Fluoroacetophenone Request for quotation
CAS: 445-27-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 445-27-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Fluoroacetophenone1 Request for quotation
CAS: 445-27-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 445-27-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
View History
Downstream Products for 2'-Fluoroacetophenone