2,4,5-Trichlorophenol
2,4,5-Trichlorophenol
CAS: 95-95-4
Molecular Formula: C6H3Cl3O
2,4,5-Trichlorophenol - Names and Identifiers
| Name | 2,4,5-Trichlorophenol |
| Synonyms | Nurelle Dowcide 2 2,4,5-TCP 202-467-8 NCI-C61187 QR BG DG EG Preventol I 2,4,5-Trichlorophenol 2,4,5-trichloro-pheno 2,4,5-TRICHLOROPHENOL phenol, 2,4,5-trichloro- epapesticidechemicalcode064210 2,4,5-trichlorophenolsaltof2,6-bis((dimethylamino)methyl)cyclohexanone |
| CAS | 95-95-4 |
| EINECS | 202-467-8 |
| InChI | InChI=1/C6H3Cl3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H |
2,4,5-Trichlorophenol - Physico-chemical Properties
| Molecular Formula | C6H3Cl3O |
| Molar Mass | 197.45 |
| Density | 1,678 g/cm3 |
| Melting Point | 64-67 °C67-69 °C (lit.) |
| Boling Point | 248 °C/740 mmHg (lit.) |
| Flash Point | 253°C |
| Water Solubility | 947.8mg/L(25 ºC) |
| Solubility | Soluble in ethanol and ligroin (U.S. EPA, 1985) |
| Vapor Presure | 3.5 at 8 °C, 22 at 25 °C (quoted, Leuenberger et al., 1985a) |
| Appearance | Powder |
| Color | Colorless needles or gray flakes from pet ether |
| Odor | strong phenolic odor |
| Merck | 14,9643 |
| BRN | 607569 |
| pKa | pK1:7.37 (25°C) |
| Storage Condition | 2-8°C |
| Stability | Stable. Note that this material creates dioxin in alkaline media at elevated temperatures. |
| Refractive Index | 1.5300 (estimate) |
| Physical and Chemical Properties | Needle-like crystals with a phenolic taste. Melting point 68 ℃, boiling point 253 ℃, relative density 1.678(25 ℃). Flammable. Soluble in ethanol, ether, acetone, benzene, carbon tetrachloride, petroleum ether and other organic solvents, almost insoluble in water. Can sublimate, with weak alkaline and strong phenolic smell. |
2,4,5-Trichlorophenol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | SN1400000 |
| TSCA | Yes |
| HS Code | 29081990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | Acute oral LD50 for guinea pigs 1,000 mg/kg, mice 600 mg/kg, rats 820 mg/kg (quoted, RTECS, 1985). |
2,4,5-Trichlorophenol - Nature
Open Data Verified Data
needle-like crystals with phenolic flavor. Melting point 68. Boiling point 253 °c. The relative density is 1. 678(25 ℃). Flammable. Almost insoluble in water, soluble in ethanol, ether, acetone, carbon tetrachloride, petroleum ether, benzene and other organic solvents.
Last Update：2024-01-02 23:10:35
2,4,5-Trichlorophenol - Preparation Method
Open Data Verified Data
tetrachlorobenzene method this is 2,4,5-the traditional process of chlorophenol production, using tetrachlorobenzene as raw material by hydrolysis.
Last Update：2022-01-01 10:41:47
2,4,5-Trichlorophenol - Use
Open Data Verified Data
can be used for the preparation of a variety of herbicides, insecticides, fungicides; As antibacterial and antiseptic, widely used in the preparation of adhesives, rubber products and anti-corrosion emulsion of textile industry. It itself can be used as a disinfectant, its sodium salt is also a fungicide and preservative, used in manufacturing and leather industry; In medicine for the synthesis of chlorpropargyl iodine, sterilization of phenol and so on.
Last Update：2022-01-01 10:41:47
2,4,5-Trichlorophenol - Safety
Open Data Verified Data
- ingestion by mistake or inhalation has high toxicity and strong irritation. Can be absorbed through the skin poisoning. Rat oral LD50 820mg/kg, guinea pig oral ld5oloooomg/kg.
- glass bottles are lined with mats or iron barrels. Store in a cool and ventilated warehouse; Carry light and remove light during handling to prevent damage to the container.
Last Update：2022-01-01 10:41:48
2,4,5-Trichlorophenol - Reference Information
| Henry's Law Constant | 1.76 at 25 °C (estimated, Leuenberger et al., 1985a) |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | can be used to prepare a variety of herbicides, pesticides, fungicides; As antibacterial and antiseptic, widely used in the preparation of adhesives, anti-corrosion emulsion for rubber products and textile industry. It itself can be used as a disinfectant, its sodium salt is also a fungicide and preservative, used in manufacturing and leather industry; In medicine for the synthesis of chlorpropargyl iodine, sterilization of phenol and so on. used as a fungicide, gas chromatography comparative sample. |
| production method | put 2,3,5, 6-tetrachlorobenzene, Solid alkali and methanol into an autoclave, the temperature was controlled at 135-152 °c and the pressure at 0.5-1.4MPa for 14H. The reaction solution was cooled to 60 ° C., and methanol was recovered by distillation, and the residue was discharged. The crystals were cooled and filtered. The crystals were dissolved in water, heated to 70 ° C., added with sodium hydrosulfite, adjusted to pH = 9.2-9.6, added with activated carbon, and decolorized at 95 ° C. For half an hour. After filtering, the filtrate was cooled to below 15 °c, hydrochloric acid was added to pH = 2-3, and 2,4, 5-trichlorophenol was filtered and dried at 45 °c to obtain a finished product. |
| category | pesticide |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 820 mg/kg; Oral-mouse LD50: 600 mg/kg |
| explosive hazard characteristics | Thermal decomposition explosive |
| flammability hazard characteristics | flammability; Toxic chloride fumes from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| extinguishing agent | water mist, foam, carbon dioxide, sand. |
| Occupational Standard | TWA 0.5 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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