2,4,6-Trimethylaniline
2,4,6-Trimethylaniline
CAS: 88-05-1
Molecular Formula: C9H13N
2,4,6-Trimethylaniline - Names and Identifiers
| Name | 2,4,6-Trimethylaniline |
| Synonyms | Mesidine 2,4,6-Trimethylanili 2,4,6-Trimethylanyline 2,4,6-Trimethylaniline 2 Minus 2-3 Methylaniline 2,4,6-trimethylbenzenamine 2,4,6-Trimethylaniline (mesidine) 2,4,6-TRIMETHYLANILINE FOR SYNTHESIS Aminomesitylene2-Amino-1,3,5-trimethylbenzeneMesidineMesitylamine |
| CAS | 88-05-1 |
| EINECS | 201-794-3 |
| InChI | InChI=1/C9H13N/c1-6-4-7(2)9(10)8(3)5-6/h4-5H,10H2,1-3H3 |
| InChIKey | KWVPRPSXBZNOHS-UHFFFAOYSA-N |
2,4,6-Trimethylaniline - Physico-chemical Properties
| Molecular Formula | C9H13N |
| Molar Mass | 135.21 |
| Density | 0.963g/mLat 25°C(lit.) |
| Melting Point | -5 °C |
| Boling Point | 108-110°C11mm Hg(lit.) |
| Flash Point | 205°F |
| Water Solubility | IMMISCIBLE |
| Vapor Presure | 0.0627mmHg at 25°C |
| Appearance | liquid (clear) |
| Color | clear brown |
| BRN | 636559 |
| pKa | pK1:4.38(+1) (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | n20/D 1.551(lit.) |
| Physical and Chemical Properties | Light yellow oil. |
| Use | Mainly used in the synthesis of dyes, is an intermediate of weak acid blue raw |
2,4,6-Trimethylaniline - Risk and Safety
| Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R26 - Very Toxic by inhalation R36/38 - Irritating to eyes and skin. R33 - Danger of cumulative effects R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 2810 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | BZ0700000 |
| TSCA | Yes |
| HS Code | 29214980 |
| Hazard Class | 6.1 |
| Packing Group | III |
2,4,6-Trimethylaniline - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 27, Sup 7) 1987 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | trimethylaniline is an intermediate widely used in dye, pesticide and other industries. The starting material for the synthesis of mesitylene is mesitylene, which is present in petroleum. With the realization of large-scale industrial production in China, the output of mesitylene is increasing, so the development of its downstream products has been paid more and more attention. Mesitylene downstream products, such as trimesic acid, trimethylaniline, M acid are important chemical products. The nitration reaction of mesitylene is the key to the synthesis of mesitylene, which is directly related to the production cost and product quality. |
| Application | both trimethylaniline pure products are colorless and transparent liquids, which are easy to change color when exposed to air and light, and the goods are often light brown. Insoluble in water, soluble in ethanol, ether and other organic solvents. Homo-trimethylaniline is an intermediate for dyes, organic pigments and pesticides. |
| preparation | 1) in a 50ml constant pressure dropping funnel, add 10g of acetic acid, then 13.5g of 98% nitric acid, it was left to stand and cooled to below 25 °c for standby. In a 24.5 ml Four-necked flask, g of acetic anhydride and 24g of mesitylene were added sequentially, and the prepared nitric acid solution was added dropwise at 20-25 ° C. While stirring. The dropwise addition was completed, and the temperature was maintained at 20~25 °c for 2H, and then increased to 35~40 °c for 2H. The sample was detected by liquid chromatography, and when Mesitylene was not detected, the reaction was terminated. The reaction equation is as follows: 2) post-treatment of nitration reaction there are two main methods for post-treatment of nitration reaction, water washing and distillation. Water washing method: After the end of the nitrification reaction, add about 40g of water to the flask, raise the temperature to 65 ℃, layer while hot, wash with hot water at 65 ℃ for 2-3 times, the organic phase is nitromesitylene. Distillation: after completion of the nitration reaction, the temperature was raised to 70 to 80 ° C., and then the acetic acid was distilled off under reduced pressure to obtain nitromesitylene. |
| uses | is mainly used in the synthesis of dyes, and is an intermediate of weak acid brilliant blue RAW intermediate of weak acid dye pramidine RAW. |
| production method | sulfuric acid and nitric acid are mixed into mixed acid, and Nitration with mesitylene is carried out at 10 ℃ and atmospheric pressure for 4H, the mixture was allowed to stand and layered, and waste acid was discharged. The resulting 2,4, 6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were reacted by reduction in a proportion of 1:3.74:0.9:2.22(mol ratio) at 100-105 ° C. For 8 hours. The crude Homo-trimethylaniline was then distilled from the reduction and purified by distillation. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:53
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