2,4-Dichloro-5-fluoropyrimidine
2,4-Dichloro-5-fluorouracil
CAS: 2927-71-1
Molecular Formula: C4HCl2FN2
2,4-Dichloro-5-fluoropyrimidine - Names and Identifiers
| Name | 2,4-Dichloro-5-fluorouracil |
| Synonyms | CHEMPACIFIC 37950 2,6-DICHLORO-5-FLUORORACIL 2,4-Dichloro-5-fluorouracil 2,4-Dichloro-5-Fluoropyrimidin 5-Fluoro-2,4-dichloropyrimdine 5-Fluoro-2,4-dichloropyrimidine 2,4-Dichloro-5-fluoropyrimidine 2,4-DICHLORO-5-FLUOROPYRIMIDINE 5-FLUORO-2,4-DICHLOROPYRIMIDINE 2,4-Dichloro-5-fluoro-pyrimidine potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate |
| CAS | 2927-71-1 |
| EINECS | 625-810-7 |
| InChI | InChI=1/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H |
| InChIKey | WHPFEQUEHBULBW-UHFFFAOYSA-N |
2,4-Dichloro-5-fluoropyrimidine - Physico-chemical Properties
| Molecular Formula | C4HCl2FN2 |
| Molar Mass | 166.97 |
| Density | 1.605±0.06 g/cm3(Predicted) |
| Melting Point | 37-41 °C (lit.) |
| Boling Point | 80 °C / 16mmHg |
| Flash Point | 223°F |
| Vapor Presure | 0.148mmHg at 25°C |
| Appearance | Powder or Crystalline Powder or Low Melting Solid |
| Color | White to pale brown |
| pKa | -3.96±0.29(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.531 |
2,4-Dichloro-5-fluoropyrimidine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3261 |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | Ⅲ |
2,4-Dichloro-5-fluoropyrimidine - Reference Information
| introduction | 2,4-dichloro-5-fluoropyrimidine is a yellow to orange crystalline solid, which can be used as an intermediate in organic synthesis and drug synthesis, and can be used to synthesize fluorocytosine. |
| Uses | 2,4-dichloro-5-fluoropyrimidine is used to synthesize two 5-fluorouracil glucuronic acid derivatives as tumor inhibitors. It was used to synthesize two 5-fluorouracil glucuronic acid derivatives as tumor inhibitors. Intermediates in organic synthesis and drug synthesis, which can be used to synthesize fluorocytosine. An intermediate of the antifungal drug flucytosine. |
| Application | 2, 4-dichloro-5-fluoropyrimidine is a heterocyclic organic substance, which can be used as an intermediate of the antifungal drug fluorocytosine. |
| Production method | It is obtained by chlorination of 5-fluorouracil. Put 5-fluorouracil and phosphorus oxychloride into a chlorination pot, stir and cool to below 20 ℃, add N,N-dimethylaniline dropwise, finish dropping, slowly raise the temperature to 110 ℃, stir for 2 hours, and cool to room temperature. The reactants are added to saturated brine and crushed ice to freeze, the temperature is maintained at 15 ℃, stirred for 1h, filtered, washed with water, and dried to obtain the finished product. |
Last Update：2024-04-10 22:29:15
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