2',3'-Anhydroadenosine
2',3'-Anhydroadenosine
CAS: 14486-22-7
Molecular Formula: C10H12N2O5
2',3'-Anhydroadenosine - Names and Identifiers
| Name | 2',3'-Anhydroadenosine |
| Synonyms | Anhydro-T 2,3'-Anhydro-T 2',3'-Anhydroadenosine 2'',3''-ANHYDROADENOSINE 2',3'-anhydro-5-methyluridine 2,4(1H,3H)-Pyrimidinedione, 1-(2,3-anhydro-β-D-lyxofuranosyl)-5-methyl- 1-(2,3-Anhydro-beta-D-lyxofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 1-(2,3-anhydro-beta-D-glycero-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione 9-[(1R,5R)-4α-(Hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2α-yl]-9H-purin-6-amine 1-[(1R,4R,5R)-4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hex-2-yl]-5-met hyl-pyrimidine-2,4-dione |
| CAS | 14486-22-7 |
| InChI | InChI=1/C10H12N2O5/c1-4-2-12(10(15)11-8(4)14)9-7-6(17-7)5(3-13)16-9/h2,5-7,9,13H,3H2,1H3,(H,11,14,15)/t5-,6?,7?,9-/m1/s1 |
2',3'-Anhydroadenosine - Physico-chemical Properties
| Molecular Formula | C10H12N2O5 |
| Molar Mass | 240.21 |
| Density | 1.505±0.06 g/cm3(Predicted) |
| Melting Point | 143.5-144.5 °C |
| Solubility | DMSO, Methanol (slightly) |
| Appearance | Solid |
| Color | White |
| pKa | 9.44±0.10(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.59 |
2',3'-Anhydroadenosine - Introduction
2 ',3'-Anhydroadenosine(2 ',3'-Dideoxyadenosine) is a nucleoside compound with the molecular formula C10H12N5O3. It is a modified form of adenosine, in which the 2 'and 3' hydroxyl groups are replaced by hydroxyl groups, so it has special application in the synthesis of deoxyribonucleotide chains.
2 ',3'-Anhydroadenosine is mainly used for the treatment of retroviruses and is an antiviral drug. It can block the replication of the virus in the cell and inhibit the spread of the virus by hindering the synthesis of viral RNA. In addition, it is also used to study the synthesis of DNA and RNA and cell biology.
Methods for preparing 2 ',3'-Anhydroadenosine are generally obtained by chemical synthesis. Specific steps include:
1. Acquiring adenine nucleoside
2. The adenine nucleoside is acylated to introduce the hydrogen-seeking group
3. The obtained compound is subjected to deprotection reaction, and the protecting group is removed to obtain 2 ',3'-Anhydroadenosine
Regarding safety information, 2 ',3'-Anhydroadenosine has low toxicity and tolerability, and is generally safe when used at appropriate doses. However, in the application process, it is still necessary to use in accordance with the doctor's advice and strict experimental operation specifications. It should be noted that for women during pregnancy and breastfeeding women, as well as patients with abnormal liver function, it needs to be used with caution and follow the doctor's recommendations.
2 ',3'-Anhydroadenosine is mainly used for the treatment of retroviruses and is an antiviral drug. It can block the replication of the virus in the cell and inhibit the spread of the virus by hindering the synthesis of viral RNA. In addition, it is also used to study the synthesis of DNA and RNA and cell biology.
Methods for preparing 2 ',3'-Anhydroadenosine are generally obtained by chemical synthesis. Specific steps include:
1. Acquiring adenine nucleoside
2. The adenine nucleoside is acylated to introduce the hydrogen-seeking group
3. The obtained compound is subjected to deprotection reaction, and the protecting group is removed to obtain 2 ',3'-Anhydroadenosine
Regarding safety information, 2 ',3'-Anhydroadenosine has low toxicity and tolerability, and is generally safe when used at appropriate doses. However, in the application process, it is still necessary to use in accordance with the doctor's advice and strict experimental operation specifications. It should be noted that for women during pregnancy and breastfeeding women, as well as patients with abnormal liver function, it needs to be used with caution and follow the doctor's recommendations.
Last Update：2024-04-09 20:52:54
