2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl)-methane
CAS: 6976-37-0
Molecular Formula: C8H19NO5
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - Names and Identifiers
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - Physico-chemical Properties
| Molecular Formula | C8H19NO5 |
| Molar Mass | 209.24 |
| Density | 1.346±0.06 g/cm3(Predicted) |
| Melting Point | 104°C(lit.) |
| Boling Point | 466.2±40.0 °C(Predicted) |
| Flash Point | 288°C |
| Water Solubility | soluble |
| Solubility | H2O: 1M at20°C, clear, colorless |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | Crystalline powder |
| Color | Yellow to orange |
| Odor | Odorless |
| Maximum wavelength(λmax) | ['λ: 280 nm Amax: 0.15'] |
| BRN | 2205275 |
| pKa | 6.5(at 25℃) |
| PH | 9.0-10.1 (20-25℃, 1M in water) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Air Sensitive |
| MDL | MFCD00002853 |
| Physical and Chemical Properties | Melting point 103-104°C. Water-soluble. |
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R21/22 - Harmful in contact with skin and if swallowed. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29221980 |
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - Reference
| Reference Show more | 1. [IF=10.182] K. Wang et al."Extracting keratin from wool by using L-cysteine."Green Chem. 2016 Jan;18(2):476-481 |
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - A method for the synthesis of Bis-Tris
Abstract:
The present invention provides a method for the synthesis of Bis-Tris, comprising:
step 1. Take 5g of sodium bisulfite and 10 ml of water to prepare the solution, then mix with 50 ml of anhydrous ethanol, and then inject ethylene oxide gas into the mixed solution to make saturated ethylene oxide aqueous solution;
step 2. The saturated solution of 100 ml is heated to 30-35 degrees, then take Tris 60g is poured into this solution and slowly dissolved after 2 hours, 20g of sodium hydroxide and 20 ml of water were added dropwise to the above solution and the pH value of the solution was controlled between 9.5 and 10.0 for 6-8 hours.
step 3. The solution after completion of the reaction in step 2 was vacuum dehydrated, and after hot filtration, anhydrous ethanol was added for dispersion, and the temperature was lowered to wait for precipitation of the product. The method for synthesizing Bis-Tris by using a saturated solution of ethylene oxide is safe and reliable, the reaction is sufficient, and the content of the product is high.
Last Update：2024-01-02 23:10:35
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol - Reference Information
| pH range of acid-base indicator discoloration | 5.8 - 7.2 |
| LogP | -2.26 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | for biological buffer buffer for detection of creatine kinase; also used to effectively protect hemoglobin in freeze-drying; Catholyte, used in IEF/2-D gel electrophoresis. |
Last Update：2024-04-09 21:01:54
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