2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol - Names and Identifiers
2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol - Introduction
2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol is an organic compound with the chemical formula C8H7F3O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol is a colorless or light yellow liquid.
-Solubility: Soluble in a variety of organic solvents, such as ethanol and dimethylformamide.
-Melting point:-15 ℃ to -10 ℃
-Boiling point: 243 ℃ to 245 ℃
-Density: 1.274g/cm³
Use:
2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol has certain application value in organic synthesis, mainly used in the following aspects:
-as a synthetic intermediate: can be used in the synthesis of pesticides, pharmaceuticals and chemicals and other organic compounds.
-As a surfactant: can be used as an emulsifier, dispersant and lubricant.
Method:
The preparation of 2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol can be carried out by the following reaction:
First, 3-fluorobenzaldehyde is reacted with sodium cyanate to obtain 3-fluorophenylformylacetonitrile. This acetonitrile is then reacted with boron tetrafluoride to produce 3-fluorophenylacetonitrile. Finally, 3-fluorophenylacetonitrile was reacted with 2,2-difluoroethanol to give 2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol.
Safety Information:
2,2-difluoro-2-(3-fluorophenyl)ethan-1-ol needs to be stored and handled properly to avoid hazards due to misuse or accidents. Here are some safety considerations:
-Avoid contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water for at least 15 minutes, and seek medical help if necessary.
-Avoid contact with oxidants and strong acids during operation and storage to prevent dangerous reactions.
-Appropriate personal protective equipment such as lab gloves, goggles, and lab coats should be provided when handling the compound.
-When handling this compound, follow the safety procedures of the laboratory, maintain good ventilation conditions, and avoid inhaling vapors or dust.
-Please refer to the substance's Safety Data Form (MSDS) for more detailed and comprehensive safety information.
Last Update：2024-04-09 21:01:54