2,3- DIHYDROPYRAN

2,3- DIHYDROPYRAN - Names and Identifiers

Name	3,4-Dihydro-2H-pyran
Synonyms	DHP Dihydropyran DIHYDROPYRAN DIHYDROPYRANE pyran,dihydro- Pyran, dihydro- δ2-dihydropyran 3,4-Dihydropyran 2,3-Dihydropyran 2,3- DIHYDROPYRAN 3,4-Dihydro-2-pyran delta2-Dihydropyran 3,4-2H-Dihydropyran 3,4-dihydro-2h-pyra 2H-3,4-Dihydropyran 3,4-Dihydro-2H-pyran 5,6-Dihydro-4H-pyran 3,4-Dihdro-2H-pyrane 2H-Pyran,3,4-dihydro- delta(Sup2)-Dihydropyran
CAS	110-87-2
EINECS	203-810-4
InChI	InChI=1/C5H8O/c1-2-4-6-5-3-1/h2,4H,1,3,5H2
InChIKey	BUDQDWGNQVEFAC-UHFFFAOYSA-N

2,3- DIHYDROPYRAN - Physico-chemical Properties

Molecular Formula	C5H8O
Molar Mass	84.12
Density	0.922 g/mL at 25 °C (lit.)
Melting Point	-70 °C (lit.)
Boling Point	86 °C (lit.)
Flash Point	4°F
Water Solubility	20 g/L (20 ºC)
Solubility	7.7g/l
Vapor Presure	77.8 hPa (20 °C)
Vapor Density	2.9 (vs air)
Appearance	Liquid
Color	Clear colorless to yellow
BRN	103493
PH	7 (5g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Stability	Volatile
Explosive Limit	1.1-13.8%(V)
Refractive Index	n20/D 1.440(lit.)
Physical and Chemical Properties	Melting point − 70°C(lit.) boiling point 86°C(lit.) density 0.922g/mL at 25°C(lit.) vapor density 2.9 (vs air) refractive index n20/D 1.440(lit.) flash point 4 °F water solubility 20g/L (20°C) BRN 103493
Use	Used as a pharmaceutical Intermediate

2,3- DIHYDROPYRAN - Risk and Safety

Risk Codes	R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. R19 - May form explosive peroxides
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S33 - Take precautionary measures against static discharges. S7/9 -
UN IDs	UN 2376 3/PG 2
WGK Germany	3
RTECS	UP7700000
TSCA	Yes
HS Code	29329995
Hazard Note	Highly Flammable/Irritant
Hazard Class	3
Packing Group	II
Toxicity	LD50 orally in Rabbit: > 4000 mg/kg

2,3- DIHYDROPYRAN - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	3, 4-dihydro-2h-pyran, abbreviated as DHP, is an organic intermediate, commonly used as a protecting group. 3, 4-dihydro-2h-pyran can be prepared from tetrahydrofurfuryl alcohol.
storage method	store in a cool and ventilated warehouse. Away from fire, heat source, anti-static. Storage temperature should not exceed 30 ℃. It should be stored separately from the oxidant, and mixed storage should not be avoided. Explosion-proof lighting and ventilation facilities shall be adopted. The use of spark-prone mechanical equipment and tools is prohibited. The storage area shall be equipped with emergency treatment equipment for leakage and appropriate containment materials.
Use	pharmaceutical intermediate, used for 1, 5-dichloropentane, and then can synthesize heptanediamine, heptanedioic acid, and for the production of synthetic fiber wait. 2, 3-hydropyran is used in the synthesis of pot and selective myeloperoxase inhibitors useful as microantial oxidants. Also is used to synthesize novel and selective σ1 receptor ligands. 3, 4-dihydro-2h-pyran is widely used as OH Protection reagent. Tetrahydropyran, pentanediol, Glutaric acid, valerolactone, pentadiene and resin products; Can also be used as pharmaceutical intermediates; Can also be used as solvents, organic synthesis intermediates; Widely used for the protection of hydroxyl groups, generally do not react with Nucleophilic Reagents and organometallic reagents, it is resistant to strong alkali and is easy to change under low pH or Lewis acid conditions. Alcohol Group-protecting reagent; Widely used reagent for hydroxyl group protection
production method	is obtained by dehydration and ring expansion of tetrahydrofurfuryl alcohol.
autoignition temperature	240°C