2,4,5-TRIMETHYLPHENYLBORONIC ACID
(2,4,5-trimethylphenyl)boronic acid
CAS: 352534-80-6
Molecular Formula: C9H13BO2
2,4,5-TRIMETHYLPHENYLBORONIC ACID - Names and Identifiers
| Name | (2,4,5-trimethylphenyl)boronic acid |
| Synonyms | 2,4,5-TRIMETHYLPHENYLBORONIC ACID 2,4,5-TriMethylphenylboronic Acid (2,4,5-trimethylphenyl)boronic acid Boronic acid, B-(2,4,5-trimethylphenyl)- Boronic acid, (2,4,5-trimethylphenyl)- (9CI) |
| CAS | 352534-80-6 |
| InChI | InChI=1/C9H13BO2/c1-6-4-8(3)9(10(11)12)5-7(6)2/h4-5,11-12H,1-3H3 |
2,4,5-TRIMETHYLPHENYLBORONIC ACID - Physico-chemical Properties
| Molecular Formula | C9H13BO2 |
| Molar Mass | 164.01 |
| Density | 1.05±0.1 g/cm3(Predicted) |
| Melting Point | 180-190°C(lit.) |
| Boling Point | 319.5±52.0 °C(Predicted) |
| Flash Point | 147°C |
| Vapor Presure | 0.000141mmHg at 25°C |
| pKa | 8.97±0.58(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.519 |
2,4,5-TRIMETHYLPHENYLBORONIC ACID - Risk and Safety
| WGK Germany | 3 |
2,4,5-TRIMETHYLPHENYLBORONIC ACID - Introduction
(2,4,5-trimethylphenyl)boronic, also known as (2,4,5-trimethylphenyl)boronic, is an organoboron compound. In its chemical structure, there are three methyl groups on a benzene ring, and the boron atom is connected to the benzene ring.
Nature:
-Appearance: slightly yellow crystalline solid.
-Melting point: about 174-176 degrees Celsius.
-Solubility: Soluble in common organic solvents, such as ethanol, dimethylformamide and ether.
Use:
- (2,4,5-trimethylphenyl)boronic acid is an important aryl boron reagent, which is widely used in organic synthesis.
-It can be used as a raw material for phenylboron reagents to construct C- C bonds and C- X bonds (X = O, N, S, etc.).
-It can also be used for copper-catalyzed alkyne-olefin phase addition reaction and coupling reaction to form aromatic compounds.
Preparation Method:
(2,4,5-trimethylphenyl)boronic acid can be prepared by the following steps:
1.2,4,5-trimethylphenyltrimethylborane (or 2,4,5-trimethylphenylboryllithium) can be obtained from toluene by oxidation and boronation.
2. Then, it reacts with acid to obtain the target product (2,4,5-trimethylphenyl)boronic acid.
Safety Information:
-As (2,4,5-trimethylphenyl)boronic acid has certain toxicity, appropriate laboratory safety measures should be taken when using it.
-Rinse immediately with water when in contact with skin and eyes.
-Store in a closed container, away from fire and oxidizing agents.
Please note that the above information is for reference only. When using and handling chemicals, always follow correct safety practices and operate in accordance with specific material safety data sheets.
Nature:
-Appearance: slightly yellow crystalline solid.
-Melting point: about 174-176 degrees Celsius.
-Solubility: Soluble in common organic solvents, such as ethanol, dimethylformamide and ether.
Use:
- (2,4,5-trimethylphenyl)boronic acid is an important aryl boron reagent, which is widely used in organic synthesis.
-It can be used as a raw material for phenylboron reagents to construct C- C bonds and C- X bonds (X = O, N, S, etc.).
-It can also be used for copper-catalyzed alkyne-olefin phase addition reaction and coupling reaction to form aromatic compounds.
Preparation Method:
(2,4,5-trimethylphenyl)boronic acid can be prepared by the following steps:
1.2,4,5-trimethylphenyltrimethylborane (or 2,4,5-trimethylphenylboryllithium) can be obtained from toluene by oxidation and boronation.
2. Then, it reacts with acid to obtain the target product (2,4,5-trimethylphenyl)boronic acid.
Safety Information:
-As (2,4,5-trimethylphenyl)boronic acid has certain toxicity, appropriate laboratory safety measures should be taken when using it.
-Rinse immediately with water when in contact with skin and eyes.
-Store in a closed container, away from fire and oxidizing agents.
Please note that the above information is for reference only. When using and handling chemicals, always follow correct safety practices and operate in accordance with specific material safety data sheets.
Last Update：2024-04-09 21:04:16
