2,4-Dichloro-6-trifluoro quinazoline

2,4-Dichloro-6-trifluoro quinazoline - Names and Identifiers

Name	2,4-dichloro-6-(trifluoromethyl)quinazoline
Synonyms	RB3371 2,4-Dichloro-6-(trifluoromethyl) 2,4-Dichloro-6-trifluoro quinazoline 2,4-Dichloro-6-(trifluoromethyl)quinazoline 2,4-dichloro-6-(trifluoromethyl)quinazoline 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE Quinazoline, 2,4-dichloro-6-(trifluoromethyl)-
CAS	864291-30-5
InChI	InChI=1/C9H3Cl2F3N2/c10-7-5-3-4(9(12,13)14)1-2-6(5)15-8(11)16-7/h1-3H

2,4-Dichloro-6-trifluoro quinazoline - Physico-chemical Properties

Molecular Formula	C9H3Cl2F3N2
Molar Mass	267.03
Density	1.595
Melting Point	100.4-102.5 °C
Boling Point	282.5±40.0 °C(Predicted)
Flash Point	88.3°C
Vapor Presure	0.152mmHg at 25°C
pKa	-1.27±0.30(Predicted)
Storage Condition	2-8℃
Refractive Index	1.571

2,4-Dichloro-6-trifluoro quinazoline - Introduction

2,4-dichloro-6-(trifluoromethyl)quinazoline is an organic compound with the chemical formula C9H4Cl2F3N. It is white crystal or white crystalline powder.

The following is about the properties of 2,4-dichloro-6-(trifluoromethyl)quinazoline:

-melting point: about 105-107 ℃
-Boiling point: about 315 ℃
-Density: 1.73g/cm³
-Solubility: Soluble in organic solvents, such as chloroform, dimethyl sulfoxide and ether, but insoluble in water.

2,4-dichloro-6-(trifluoromethyl)quinazoline has important applications in the field of medicine and is used as an intermediate for some drugs. It can be used to synthesize biologically active compounds, such as anti-tumor drugs.

The method for preparing 2,4-dichlororo-6-(trifluoromethyl)quinazoline is generally by reacting 2,4-dichloroquinazoline with trimethyl hydrofluorate, and then adding sodium perchlorate, and finally obtaining the target product. This is a more commonly used synthetic route, but other different synthetic methods are also possible.

Regarding safety information, 2,4-dichloro-6-(trifluoromethyl)quinazoline is an organic compound and should be used with caution. It may be irritating to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as gloves, safety glasses and face mask when handling. It should also be used in a well-ventilated place and away from open flames and high temperatures. If contact or ingestion occurs, rinse immediately with plenty of water and seek medical attention.

Last Update：2024-04-09 20:49:11