2,4-dihydroxy 3-nitro pyridine
2,4-Dihydroxy-3-nitropyridine
CAS: 89282-12-2
Molecular Formula: C5H4N2O4
2,4-dihydroxy 3-nitro pyridine - Names and Identifiers
2,4-dihydroxy 3-nitro pyridine - Physico-chemical Properties
| Molecular Formula | C5H4N2O4 |
| Molar Mass | 156.1 |
| Density | 1.65±0.1 g/cm3(Predicted) |
| Melting Point | 265°C (dec.) |
| Boling Point | 305.6±42.0 °C(Predicted) |
| Appearance | Bright yellow crystal |
| BRN | 149558 |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD01075671 |
2,4-dihydroxy 3-nitro pyridine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37 - Wear suitable gloves. |
| UN IDs | 3335 |
| HS Code | 29333990 |
2,4-dihydroxy 3-nitro pyridine - Reference Information
| introduction | 2,4-dihydroxy -3-nitropyridine is white or light yellow solid at normal temperature and pressure. it belongs to pyridine heterocyclic compounds. due to the hydroxyl group in the structure, the enol structure is different to form a carbonyl structure to obtain the molecular structure of amide, it is a material additive and pharmaceutical chemical intermediate. |
| Use | 2, 4-dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemistry and organic synthesis intermediate. In the synthetic transformation, the hydroxyl group in the structure may be affected by the influence of cyclopyridine and nitro group and can be easily converted into halogen atoms, it should be noted that by changing the reaction conditions, two hydroxyl groups can selectively halogenate one or convert two at one time. In addition, liquid bromine can be used to introduce a bromine atom at the 5th position of pyridine under acidic conditions. |
| synthesis | 2, 4-dihydroxypyridine (13)(4.95kg, 43.2 mol) is slowly added into cooled (0-20 ℃) concentrated sulfuric acid (15 liters) in batches, and the reactants are stirred for 35 minutes, then slowly add fuming nitric acid (2L) at a rate of keeping the internal temperature below 5 degrees (adding time 4.5 hours), then add cold water (6 liters), and keep the internal temperature below 5 degrees (adding time 2.6 hours) and add the remaining 54 liters of water (adding time 1.25 hours) at a rate of raising the internal temperature to 15 degrees. The slurry is cooled to 8 degrees to obtain a precipitate, filtered (2 hours) and washed with water (2 × 20L), and the target product 2, 4-dihydroxy-3-nitropyridine is obtained by drying the solid in a 75-degree vacuum furnace under nitrogen atmosphere. Figure 2. Synthetic route of 4-dihydroxy-3-nitropyridine |
Last Update：2024-04-09 20:52:54
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