2,5-DICHLOROPYRIMIDINE
2,5-DICHLOROPYRIMIDINE
CAS: 22536-67-0
Molecular Formula: C4H2Cl2N2
2,5-DICHLOROPYRIMIDINE - Names and Identifiers
| Name | 2,5-DICHLOROPYRIMIDINE |
| Synonyms | 2,5-chloropyrimidine 2,5-DICHLOROPYRIMIDINE 2,5-Dichloro-1,3-diazine Pyrimidine, 2,5-dichloro- Pyrimidine, 2,5-dichloro- (7CI,8CI,9CI) |
| CAS | 22536-67-0 |
| EINECS | 639-415-2 |
| InChI | InChI=1/C4H2Cl2N2/c5-3-1-7-4(6)8-2-3/h1-2H |
2,5-DICHLOROPYRIMIDINE - Physico-chemical Properties
| Molecular Formula | C4H2Cl2N2 |
| Molar Mass | 148.98 |
| Density | 1.493 |
| Melting Point | 48-55 °C |
| Boling Point | 190°C |
| Flash Point | 140°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.0152mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | Off-white |
| Maximum wavelength(λmax) | ['268nm(EtOH)(lit.)'] |
| pKa | -2.84±0.22(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.559 |
| MDL | MFCD00673131 |
| Physical and Chemical Properties | Off-white crystals |
| Use | This product is for scientific research only and shall not be used for other purposes. |
2,5-DICHLOROPYRIMIDINE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 2 |
| HS Code | 29335990 |
| Hazard Class | 9 |
| Packing Group | Ⅲ |
2,5-DICHLOROPYRIMIDINE - Introduction
2,5-dichloropyrimidine is an organic compound with the chemical formula C4H2Cl2N2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,5-dichloropyrimidine is a white solid.
-Solubility: Its solubility in water is low, but it is soluble in many organic solvents.
Use:
-Chemical synthesis: 2,5-dichloropyrimidine is an intermediate widely used in the synthesis of other compounds. It is often used in the preparation of pesticides, drugs, dyes and other organic compounds.
-Drug: The compound also has certain application potential in drug research, and can be used as a precursor of anti-cancer and anti-tuberculosis drugs.
Method:
-The preparation of 2,5-dichloropyrimidine can be obtained by reacting 2,5-dinitropyrimidine with sodium bisulfite in ethanol. First, 2,5-dinitropyrimidine is reacted with sodium bisulfite to form nitropyrimidine, which is then reduced with aluminum chloride or stannous acid to give 2,5-dichloropyrimidine.
Safety Information:
- 2,5-dichloropyrimidine has low toxicity under General use conditions, but it is still necessary to comply with general safety operating procedures.
-Wear protective gloves, goggles and a protective mask to prevent irritation to the skin, eyes or respiratory tract.
-It should be operated in a well-ventilated environment to avoid inhaling the dust of the substance.
-Because 2,5-dichloropyrimidine has certain toxicity to the environment, waste should be disposed of correctly after use to avoid pollution to the environment.
Please note that the above information is for reference only. In actual operation, the instructions and safe operation guidelines for specific chemical substances should be followed.
Nature:
-Appearance: 2,5-dichloropyrimidine is a white solid.
-Solubility: Its solubility in water is low, but it is soluble in many organic solvents.
Use:
-Chemical synthesis: 2,5-dichloropyrimidine is an intermediate widely used in the synthesis of other compounds. It is often used in the preparation of pesticides, drugs, dyes and other organic compounds.
-Drug: The compound also has certain application potential in drug research, and can be used as a precursor of anti-cancer and anti-tuberculosis drugs.
Method:
-The preparation of 2,5-dichloropyrimidine can be obtained by reacting 2,5-dinitropyrimidine with sodium bisulfite in ethanol. First, 2,5-dinitropyrimidine is reacted with sodium bisulfite to form nitropyrimidine, which is then reduced with aluminum chloride or stannous acid to give 2,5-dichloropyrimidine.
Safety Information:
- 2,5-dichloropyrimidine has low toxicity under General use conditions, but it is still necessary to comply with general safety operating procedures.
-Wear protective gloves, goggles and a protective mask to prevent irritation to the skin, eyes or respiratory tract.
-It should be operated in a well-ventilated environment to avoid inhaling the dust of the substance.
-Because 2,5-dichloropyrimidine has certain toxicity to the environment, waste should be disposed of correctly after use to avoid pollution to the environment.
Please note that the above information is for reference only. In actual operation, the instructions and safe operation guidelines for specific chemical substances should be followed.
Last Update：2024-04-09 21:04:16
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