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2,5-dihydroxy-benzenesulfonic aci calcium salt

Calcium Dobesilate

CAS: 20123-80-2

Molecular Formula: 2C6H5O5S.Ca

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2,5-dihydroxy-benzenesulfonic aci calcium salt - Names and Identifiers

Name Calcium Dobesilate
Synonyms doxium
dexium
Calcium Dobesilate
CALCIUM DOBESILATE
CALCIUM DOBESILATE 1-HYDRATE
CALIUM DOBESILATE MONOHYDRATE
Calcium Dobesilate Mnohydrate
calcium bis(2,5-dihydroxybenzenesulfonate)
2,5-dihydroxy-benzenesulfonic aci calcium salt
2,5-Dihydroxybenzenesulfonic acid, calcium salt
CAS 20123-80-2
EINECS 243-531-5
InChI InChI=1/2C6H6O5S.Ca.H2O/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;;/h2*1-3,7-8H,(H,9,10,11);;1H2/q;;+2;/p-2
InChIKey QGNBTYAQAPLTMX-UHFFFAOYSA-L

2,5-dihydroxy-benzenesulfonic aci calcium salt - Physico-chemical Properties

Molecular Formula2C6H5O5S.Ca
Molar Mass418.41
Melting Point>300° (dec)
Solubility H2O: soluble15mg/mL, clear
Appearancepowder
Colorwhite to beige
Storage ConditionInert atmosphere,Room Temperature
StabilityHygroscopic
Physical and Chemical PropertiesThis product is white or white hygroscopic powder, odorless, bitter in taste, easy to deteriorate in light, with hygroscopicity. This product is very soluble in water, soluble in ethanol or acetone, very slightly soluble in chloroform or ether.
UseUsed as microvascular nutrition medicine

2,5-dihydroxy-benzenesulfonic aci calcium salt - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
Hazard ClassIRRITANT
ToxicityLD50 in mice: 700 mg/kg (Esteve-Subirana)

2,5-dihydroxy-benzenesulfonic aci calcium salt - Reference Information

Pharmacological effects 1. Calcium dobesilate has the effect of inhibiting vasoactive substances (histamine, serotonin, bradykinin, hyaluronidase, prostaglandin) on microvessels. The high permeability of the blood vessel reduces the damage of the vascular intima, improves the biosynthesis of basement membrane collagen, improves the permeability of the capillary wall, and improves the flexibility of red blood cells, the blood viscosity is reduced, and the lymphatic reflux is improved, thereby reducing the pathological high permeability of the microvascular wall.
2. Calcium dobesilate can reduce the levels of fibrinogen and globulin, reduce the high polymerization of red blood cells, activate the activity of fibrinase, increase the dissolving ability of blood fibrin, thereby reducing blood viscosity. Reduce the synthesis and release of platelet aggregation factor, inhibit a variety of aggregation factors, cause aggregation reaction and platelet spontaneous aggregation, reduce platelet activity, prevent thrombosis, its effect is dose-related.
3. For microvascular disease, calcium dobesilate can increase the caliber of arterioles and veins, increase the number of capillary openings, significantly accelerate blood flow, and significantly improve microcirculation. Eliminate or relieve edema, capillary bleeding, lower limb heaviness and pressure.
4. Calcium dobesilate significantly reduced the content of sorbitol, blocked the channel of sugar to sorbitol, and inhibited the dysfunction caused by the increase of sorbitol in blood cells.
adverse reactions calcium dobesilate has very little chance of side effects. the main adverse reactions are fever (26%), gastrointestinal discomfort (12.5%), skin reaction (8.2%), arthralgia (4.3%) and granulocytopenia (4.3%). no death has been reported.
pharmacokinetics after administration of 500mg calcium dobesilate for oral administration, the blood drug concentration level during the 3rd and 10th hours was above 6 μg/ml, and after 6 hours (t maximum) the blood drug concentration (c maximum) reached the maximum, with an average of 8 μg/ml. The blood concentration at 24h after medication was about 3 μg/ml. The protein binding rate is 20% ~ 25%. Trace amounts are present in breast milk. Calcium dobesilate will not enter the enterohepatic circulation, it is mainly excreted in its original form, and only 10% is excreted as metabolites. Within 24 hours after administration, about an oral dose of 50% is excreted in urine and about 50% in feces. The plasma half-life is about 5h.
Overview Calcium dobesilate (calciumdobesilate, the trade names include Zhishengming, Dobes, Andomin, Haochang, etc.), chemical name 2, 5-Calcium dihydroxybenzene sulfonate monohydrate. It is a vasodilator that selectively acts on the wall of the capillary tube. It can not only adjust and improve the permeability and fragility of the capillary wall, but also inhibit active substances such as bradykinin. It is mainly used to treat capillary diseases caused by various reasons, such as diabetic retinopathy, varicose veins, and phlebitis, Leg spasm, sputum itching dermatitis and other symptoms. This product has high bioavailability, low toxicity and high therapeutic index. It is an ideal therapeutic drug for capillary diseases.
use as microvascular nutrition drug
Last Update：2024-04-09 21:21:28
2,5-dihydroxy-benzenesulfonic aci calcium salt
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
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CAS: 20123-80-2
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
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CAS: 20123-80-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Wechat: 18301782025
Wuhan Boye Science And Technology Development Co., Ltd.
Product Name: Calcium dobesilate Request for quotation
CAS: 20123-80-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
Hubei Marvel-Bio Medicine
Product Name: Calcium dobesilate Request for quotation
CAS: 20123-80-2
Tel: 02787737261
Email: 2295636945@qq.com
Mobile: 15387132319
QQ: 2295636945 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Calcium Dobesilate Visit Supplier Webpage Request for quotation
CAS: 20123-80-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Calcium Dobesilate Request for quotation
CAS: 20123-80-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Calcium Dobesilate Visit Supplier Webpage Request for quotation
CAS: 20123-80-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Wuhan Boye Science And Technology Development Co., Ltd.
Product Name: Calcium dobesilate Request for quotation
CAS: 20123-80-2
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380 Click to send a QQ message
Wechat: 15387090420
Hubei Marvel-Bio Medicine
Product Name: Calcium dobesilate Request for quotation
CAS: 20123-80-2
Tel: 02787737261
Email: 2295636945@qq.com
Mobile: 15387132319
QQ: 2295636945 Click to send a QQ messageSend QQ message
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2,5-dihydroxy-benzenesulfonic aci calcium salt
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