2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile
3-cyano-2,6-dichloro-4-(trifluoromethyl)pyridine
CAS: 13600-42-5
Molecular Formula: C7HCl2F3N2
2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile - Names and Identifiers
2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile - Physico-chemical Properties
| Molecular Formula | C7HCl2F3N2 |
| Molar Mass | 241 |
| Density | 1.63±0.1 g/cm3(Predicted) |
| Melting Point | 38 °C |
| Boling Point | 282.4±35.0 °C(Predicted) |
| Flash Point | 97.1°C |
| Vapor Presure | 0.0461mmHg at 25°C |
| Appearance | White solid |
| pKa | -6.82±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.456 |
| MDL | MFCD00084977 |
2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3439 |
| Hazard Class | TOXIC |
2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile - Introduction
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine is an organic compound whose chemical formula is C8H2Cl2F3N. The following is a description of its nature, use, preparation and safety information:
Nature:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine is a colorless to pale yellow solid. It has a melting point of about 44-46°C and a boiling point of about 236°C. It is soluble in organic solvents, such as ethanol and dichloromethane, and insoluble in water. It is a relatively stable compound.
Use:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine has a variety of uses in organic synthesis. It can be used as a reagent and catalyst in organic synthesis, and is commonly used in fluorination and diazotization reactions. It can also be used in the synthesis of pesticides and pharmaceutical intermediates.
Preparation Method:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine can be prepared in a variety of ways. A common method is the reaction of 2,6-dichloro -4-(trifluoromethyl) pyridine with sodium cyanide in an organic solvent to give the product. The specific reaction conditions can be adjusted according to the specific situation.
Safety Information:
3-cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine has low toxicity, but it is still necessary to pay attention to safe operation. Contact with the skin or inhalation of its gases may cause mild irritation. When handling this compound, it is recommended to wear appropriate protective gloves and breathing apparatus to avoid contact with the skin and inhalation of its gases. The compound should be handled and stored in the laboratory to avoid leakage or reaction with other chemicals.
Nature:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine is a colorless to pale yellow solid. It has a melting point of about 44-46°C and a boiling point of about 236°C. It is soluble in organic solvents, such as ethanol and dichloromethane, and insoluble in water. It is a relatively stable compound.
Use:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine has a variety of uses in organic synthesis. It can be used as a reagent and catalyst in organic synthesis, and is commonly used in fluorination and diazotization reactions. It can also be used in the synthesis of pesticides and pharmaceutical intermediates.
Preparation Method:
3-Cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine can be prepared in a variety of ways. A common method is the reaction of 2,6-dichloro -4-(trifluoromethyl) pyridine with sodium cyanide in an organic solvent to give the product. The specific reaction conditions can be adjusted according to the specific situation.
Safety Information:
3-cyano-2, 6-dichloro-4-(trifluoromethyl) pyridine has low toxicity, but it is still necessary to pay attention to safe operation. Contact with the skin or inhalation of its gases may cause mild irritation. When handling this compound, it is recommended to wear appropriate protective gloves and breathing apparatus to avoid contact with the skin and inhalation of its gases. The compound should be handled and stored in the laboratory to avoid leakage or reaction with other chemicals.
Last Update：2024-04-09 15:17:52
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