2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

Name	2-[2-(2-Propynyloxy)ethoxy]ethylamine
Synonyms	Alkyne-PEG2-NH2 H2N-PEG2-Propyne HC≡C-CH2-PEG2-NH2 Propargyl-PEG2-NH2 Propyne-PEG2-amine Propargyl-PEG2-amine 2-[2-(2-Propynyloxy)ethoxy]ethylamine 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
CAS	944561-44-8

Molecular Formula	C7H13NO2
Molar Mass	143.18
Density	0.992±0.06 g/cm3(Predicted)
Boling Point	213.8±20.0 °C(Predicted)
pKa	8.72±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.4590 to 1.4630
Physical and Chemical Properties	Bioactive Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG2-amine is a PROTAC linker and belongs to the PEG class. Propargyl-PEG2-NH2 can be used to synthesize a series of PROTAC molecules.
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

biological activity	Propargyl-PEG2-amine is a non-cleavable ADC linker for the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG2-amine is a PROTAC linker and belongs to the PEG class. Propargyl-PEG2-NH2 can be used to synthesize a series of PROTAC molecules.
target	Non-cleavable PEGs
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-09 21:04:16