2-(Chloromethyl)pyridine
2-Chloromethylpyridine
CAS: 4377-33-7
Molecular Formula: C6H6ClN
2-(Chloromethyl)pyridine - Names and Identifiers
| Name | 2-Chloromethylpyridine |
| Synonyms | AKOS B006588 2-Chloromethyl -Chloro-picoline 2-Picolyl chloride ART-CHEM-BB B006588 2-CHLOROMETHYLPYRIDINE 2-Chloromethylpyridine 2-Chloromethyl Pyridine 2-Pyridylmethyl chloride 2-(Chloromethyl)pyridine Pyridine,2-(chloroMethyl)- |
| CAS | 4377-33-7 |
| EINECS | 230-149-9 |
| InChI | InChI=1/C6H6ClN/c7-5-6-3-1-2-4-8-6/h1-4H,5H2 |
2-(Chloromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H6ClN |
| Molar Mass | 127.57 |
| Density | 1.156±0.06 g/cm3(Predicted) |
| Melting Point | 79 °C |
| Boling Point | 73-76 °C(Press: 10 Torr) |
| Flash Point | 83.7°C |
| Vapor Presure | 0.873mmHg at 25°C |
| pKa | 3.76±0.12(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.53 |
| Physical and Chemical Properties | Liquid. Boiling Point 73-76 °c (1.33kPa), 45-47 °c (67PA), refractive index 1.5365. Very unstable. |
2-(Chloromethyl)pyridine - Risk and Safety
| UN IDs | 3265 |
| Hazard Class | 8 |
| Packing Group | Ⅲ |
2-(Chloromethyl)pyridine - Reference Information
| use | intermediate of chlorpheniramine. |
| Production method | It is obtained by chlorination of 2-methylpyridine. Add 2-methylpyridine and anhydrous carbon tetrachloride to the reaction pot, stir and mix, add dried sodium carbonate, heat to 58-60 ℃, start to pass chlorine under light, keep the temperature at 60-65 ℃, and finish with chlorine at about 6h. Stir for 0.5h, cool to 30 ℃, add water to dissolve sodium carbonate, adjust pH to 8-9 with liquid alkali, and let stand to remove the water layer. The carbon tetrachloride layer was extracted with 20% hydrochloric acid to obtain 2-methylpyridine hydrochloride [6959-47-3] with a melting point of 128-129 ℃. |
Last Update：2024-04-09 20:52:54
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