2-(tert-butoxycarbonyl(2-chlorophenyl)amino)acetic acid

2-(tert-butoxycarbonyl(2-chlorophenyl)amino)acetic acid - Names and Identifiers

Name	(S)-N-Boc-(2'-chlorophenyl)glycine
Synonyms	(S)-Boc-Phg(2-Cl)-OH N-Boc-S-2-Chlorophenylglycine (S)-Boc-2-(2-Chlorophenyl)glycine (S)-N-Boc-(2'-chlorophenyl)glycine 2-(tert-butoxycarbonyl(2-chlorophenyl)amino)acetic acid (2S)-[(tert-Butoxycarbonyl)amino](2-chlorophenyl)acetic acid (2R)-[(tert-butoxycarbonyl)amino](2-chlorophenyl)ethanoic acid (2S)-[(tert-butoxycarbonyl)amino](2-chlorophenyl)ethanoic acid (2S)-2-{[(tert-butoxy)carbonyl]aMino}-2-(2-chlorophenyl)acetic acid (2S)-2-(2-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid Benzeneacetic acid, 2-chloro-α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)- Benzeneacetic acid, 2-chloro-alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-, (alphaS)-
CAS	225918-60-5
InChI	InChI=1/C13H16ClNO4/c1-13(2,3)19-12(18)15-10(11(16)17)8-6-4-5-7-9(8)14/h4-7,10H,1-3H3,(H,15,18)(H,16,17)/t10-/m1/s1

2-(tert-butoxycarbonyl(2-chlorophenyl)amino)acetic acid - Physico-chemical Properties

Molecular Formula	C13H16ClNO4
Molar Mass	285.72
Density	1.272±0.06 g/cm3(Predicted)
Boling Point	431.5±40.0 °C(Predicted)
Flash Point	214.8°C
Vapor Presure	3.27E-08mmHg at 25°C
pKa	3.26±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.543

2-(tert-butoxycarbonyl(2-chlorophenyl)amino)acetic acid - Introduction

(S)-N-Boc-(2 '-chlorophenyl)glycine is an organic compound whose chemical formula is C17H19ClNO4. In the chemical structure, it is (S) the-glycine is substituted at the 2'-position by a chlorophenyl group with a Boc protecting group. The following describes its nature, use, preparation and safety information:

Properties:(S)-N-Boc-(2 '-chlorophenyl)glycine is a colorless crystalline solid, highly soluble in chloroform, dichloromethane and ethanol, insoluble in water. It has a unique chiral structure and can be used as an important intermediate for Chiral synthesis.

Purpose:(S)-N-Boc-(2 '-chlorophenyl)glycine is widely used in the field of organic chemistry, mainly for Chiral synthesis reactions. It can be used as a chiral specific reagent, Catalyst or ligand. It has important applications in drug synthesis, natural product synthesis and asymmetric synthesis, such as the synthesis of chiral drugs and pesticides.

Preparation method: A common method for preparing (S)-N-Boc-(2 '-chlorophenyl)glycine is by reacting (S)-Glycine is obtained by amidation reaction with 2'-chlorobenzoic acid and Boc2O (tert-butoxycarbonyl chloride) in the presence of a base. Inert solvents, such as methylene chloride and chloroform, are also generally required in the reaction conditions and the reaction is facilitated by cooling the reaction mixture.

Safety Information:(S)-N-Boc-(2 '-chlorophenyl)glycine has certain chemical activity, so it is necessary to follow certain safety precautions during operation. Avoid direct contact with skin and eyes, and wear appropriate personal protective equipment such as lab gloves and goggles when using. In addition, it should be stored in a dry, cool place and away from fire and oxidizing agents.

Last Update：2024-04-09 20:52:54