2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
CAS: 77544-60-6
Molecular Formula: C15H24O7S
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Names and Identifiers
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Physico-chemical Properties
| Molecular Formula | C15H24O7S |
| Molar Mass | 348.41 |
| Density | 1.202 g/mL at 25 °C |
| Boling Point | 492.5±40.0 °C(Predicted) |
| Flash Point | >110℃ |
| pKa | 14.36±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D1.507 |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R34 - Causes burns R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2927 8(6.1) / PGII |
| WGK Germany | 3 |
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Upstream Downstream Industry
| Downstream Products | S-Acetyl-PEG3-Azido 1-mercapto-11-hydroxy-3,6,9-trioxaundecane Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]- O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL H2N-PEG4-tBu |
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Reference Information
| biological activity | Tetraethylene glycol monotosylate is a degradable (cleavable) acylhydrazone-based ADC linker used to synthesize antibody-coupled drugs (ADCs). Tetraethylene glycol monotosylate can also be used as Linker of PROTAC and can be used for synthesis of PROTAC. |
| target | Cleavable PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-10 22:29:15
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol - Uses and synthesis methods
biological activity
Tetraethylene glycol monotosylate is a degradable (cleavable) acylhydrazone-based ADC linker used to synthesize antibody-coupled drugs (ADCs). Tetraethylene glycol monotosylate can also be used as Linker of PROTAC and can be used for synthesis of PROTAC.
target
Cleavable
PEGs
in vitro study
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Last Update：2024-04-10 22:29:15
![2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol](http://res.chembk.com/assets/images/structure/62921-76-0.png)
Supplier List
Spot supply
Product Name: Tos-PEG4 Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol Visit Supplier Webpage Request for quotation
CAS: 77544-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 77544-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Tos-PEG4 Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol Visit Supplier Webpage Request for quotationCAS: 77544-60-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol Visit Supplier Webpage Request for quotation
CAS: 77544-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 77544-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
METHYL CELLOSOLVE(R)
CADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULAR
2-氨基-5-甲基-4-苯基-3-氰基噻吩
N-乙基-3-氰基-4-甲基-6-羟基-2-吡啶酮
3-碘-2-羟基-5-硝基吡啶
1-环丙基-8-甲氧基-6-氟-7-氯-1,4-二氢-4-羰基喹啉-3-羧酸
Acetyl chloride, 1M solution in dichloromethane, AcroSeal
SAGE OIL, DALMATION, SPANISH TYPE
barium(2+),oxygen(2-),tin(4+)
METHYL CELLOSOLVE(R)
CADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULARCADMIUM, METAL, 20-60 MESH, GRANULAR
2-氨基-5-甲基-4-苯基-3-氰基噻吩
N-乙基-3-氰基-4-甲基-6-羟基-2-吡啶酮
3-碘-2-羟基-5-硝基吡啶
1-环丙基-8-甲氧基-6-氟-7-氯-1,4-二氢-4-羰基喹啉-3-羧酸
Acetyl chloride, 1M solution in dichloromethane, AcroSeal
SAGE OIL, DALMATION, SPANISH TYPE
barium(2+),oxygen(2-),tin(4+)
Downstream Products for 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
S-Acetyl-PEG3-Azido
1-mercapto-11-hydroxy-3,6,9-trioxaundecane
Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL
H2N-PEG4-tBu
1-mercapto-11-hydroxy-3,6,9-trioxaundecane
Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-
O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL
H2N-PEG4-tBu