2-呋喃甲胺,呋喃甲胺,麸胺,麦胺
Furfurylamine
CAS: 617-89-0
Molecular Formula: C5H7NO
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Names and Identifiers
| Name | Furfurylamine |
| Synonyms | Furfurylamine furan-2-amine 2-FURFURYLAMINE AKOS BBS-00003604 2-Aminomethylfuran 2-Furanmethanamine 2-AMINOMETHYLFURAN 2-FURANMETHYLAMINE 2-FURYLMETHYLAMINE 1-(2-FURYL)METHYLAMINE 1-(2-Furyl)methylamine 1-(2-furyl)-methylamin furan-2-ylmethanaminium 1-(furan-2-yl)methanamine |
| CAS | 617-89-0 |
| EINECS | 210-536-9 |
| InChI | InChI=1/C5H7NO/c6-4-5-2-1-3-7-5/h1-3H,4,6H2/p+1 |
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Physico-chemical Properties
| Molecular Formula | C5H7NO |
| Molar Mass | 97.12 |
| Density | 1.099g/mLat 25°C(lit.) |
| Melting Point | −70°C(lit.) |
| Boling Point | 145-146°C(lit.) |
| Flash Point | 116°F |
| Water Solubility | soluble |
| Vapor Presure | 4 mm Hg ( 20 °C) |
| Vapor Density | 3.35 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to yellow-brown |
| BRN | 1614 |
| pKa | 9.12±0.29(Predicted) |
| PH | 11.6 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Air Sensitive |
| Explosive Limit | 1.8%(V) |
| Refractive Index | n20/D 1.490(lit.) |
| Physical and Chemical Properties | Density 1.099 melting point -70°C boiling point 145-146°C refractive index 1.489-1.491 flash point 37°C water-soluble solution |
| Use | For pharmaceutical and Organic synthesis |
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Risk and Safety
| Risk Codes | R10 - Flammable R21/22 - Harmful in contact with skin and if swallowed. R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S23 - Do not breathe vapour. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2526 3/PG 3 |
| WGK Germany | 3 |
| RTECS | LU9275000 |
| TSCA | Yes |
| HS Code | 29321900 |
| Hazard Note | Harmful/Corrosive/Flammable |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 200 - 2000 mg/kg LD50 dermal Rat 100 mg/kg |
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Nature
Open Data Verified Data
colorless transparent liquid. Boiling point 145~146 deg C. The relative density was 1. 099. Refractive index 4900. Miscible with water, soluble in ethanol ether, flammable, Flash Point 46 ℃, irritant.
Last Update：2024-01-02 23:10:35
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Preparation Method
Open Data Verified Data
obtained by hydrogenation and ammonification of furfural., O, H:c)H ~ hl,, 0/a c 'J l? NH 2 put furfural and catalyst Raney nickel into a stainless steel reactor, and then add ammonia-saturated methanol; Then replace the air in the reactor with nitrogen, and then pass hydrogen at 45~60 ℃, 8MPa under the stirring of hydrogen absorption 4H, to the kettle pressure does not become the end point. The reaction was filtered, and the filtrate was recovered with methanol to the end. Distillation was carried out under reduced pressure to collect the 45~67 ℃[0~5.3kPa] fraction, which is furfurylamine, with a yield of about 40%
.Last Update：2022-01-01 10:57:08
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Use
Open Data Verified Data
This product is used for organic synthesis, and 2, 4-chloro-5-sulfamoylbenzoic acid condensation, can be a potent diuretic drug "furosemide"; "furosemide" as a diuretic drug role strong and fast, it is a drug necessary for the treatment of severe edema. Furfurylamine is also used as an anti-corrosion agent.
Last Update：2022-01-01 10:57:08
2-呋喃甲胺,呋喃甲胺,麸胺,麦胺 - Reference Information
| LogP | 0.37 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | 2-furan methylamine, also known as furfuramine, is miscible with water and soluble in ethanol and ether. Absorb carbon dioxide in the air for deterioration. Used as raw materials for medicine. It is also used as an anti-corrosion agent. It is obtained by furfural ammoniation and catalytic hydrogenation. |
| Application | 2-furan methylamine is an important organic synthetic intermediate and chemical product. 2-furan methylamine and its derivatives are widely used in the pharmaceutical industry. For example, it is condensed with 2, 4-dichloro-5-aminosulfonylbenzoic acid to produce a powerful diuretic drug "furosemide" with strong diuretic effect and fast effect, it is an essential drug for the treatment of severe edema; in addition, 2-furamide is also used as a corrosion inhibitor, flux, etc. |
| use | for organic synthesis. The condensation of furfuramine and 2, 4-dichloro-5-aminosulfonyl benzoic acid can be a powerful diuretic furosemide. Furosemide has a strong and fast diuretic effect. It is a necessary drug for the treatment of subsevere edema. Furfuran is also used as an anti-corrosion agent. It can be used as a pharmaceutical intermediate, can synthesize a powerful diuretic "furosemide", and can also be used as an anti-corrosion agent. Used as corrosion inhibitor and flux. for organic synthesis. for pharmaceutical and organic synthesis |
| Production method | is obtained by furfural ammoniation and catalytic hydrogenation. Put furfural and nickel into a stainless steel reactor, and then add ammonia-saturated methanol. Nitrogen is passed to replace the air in the kettle, then hydrogen is passed, and hydrogen is stirred and absorbed at 45-60 ℃ and 8.8MPa for 4 hours until the kettle pressure does not become the end point. The reactants are filtered, the filtrate is recovered to the end of methanol, the distillation is reduced pressure, and the fraction at 45-67 ℃(0-5.32kPa) is collected, which is furfuramine, and the yield is about 40%. |
| category | more flammable liquid |
| toxicity classification | |
| acute toxicity | abdominal cavity-mouse LDL0: 200 mg/kg |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; toxic nitrogen oxide smoke from combustion |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
| spontaneous combustion temperature | 350°C DIN 51794 |
Last Update：2024-04-09 21:01:54
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