2-(羟亚氨基)乙酰乙酸乙酯

2-(羟亚氨基)乙酰乙酸乙酯 - Names and Identifiers

Name	ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE
Synonyms	NSC 10758 AURORA KA-158 OXIMINOACETOACETIC ESTER Ethyl2-(hydroxyimino)acetoacetate ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE ethyl (2E)-2-(hydroxyimino)-3-oxobutanoate Butyric acid, α,β-dioxo-, ethyl ester α-oxiMe (4CI) Butyric acid, 2,3-dioxo-, ethyl ester, 2-oxiMe (6CI,7CI,8CI)
CAS	5408-04-8

2-(羟亚氨基)乙酰乙酸乙酯 - Physico-chemical Properties

Molecular Formula	C6H9NO4
Molar Mass	159.14
Density	1.22±0.1 g/cm3(Predicted)
Melting Point	46-48°C
Boling Point	136-137 °C(Press: 5 Torr)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Yellow Low-Melting
pKa	7.41±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Use	Use is an intermediate of cimetidine.

2-(羟亚氨基)乙酰乙酸乙酯 - Risk and Safety

Hazard Class

IRRITANT

2-(羟亚氨基)乙酰乙酸乙酯 - Upstream Downstream Industry

Downstream Products

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER
ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE

2-(羟亚氨基)乙酰乙酸乙酯 - Introduction

ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE, also known as ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or light yellow liquid
-Molecular formula: C7H11NO4
-Molecular Weight: 173.17
-Melting point: No data
-Boiling Point: 182-185 ℃
-Density: 1.238g/cm³
-Solubility: Soluble in alcohol and ether, insoluble in water

Use:
- ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE is useful as an intermediate in organic synthesis.
-It can be used to synthesize drugs in the field of medicine.
-can also be used for the synthesis of pesticides.

Method:
The preparation method of ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE is more complicated. A common method is as follows:
-First, ethyl acetoacetate is reacted with hydrofluoric acid to produce ethyl acetoacetate fluoride derivative.
-Then, the ETHYL acetoacetate fluoride derivative is reacted with hydroxime to generate ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE.

Safety Information:
- ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE is a chemical and should be operated safely when using it.
-Wear protective clothing, chemical goggles and chemical gloves during operation.
-Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
-Storage should be sealed and kept away from fire and oxidizing agents.

Last Update：2024-04-09 21:01:54