2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid

Name	UMI-77
Synonyms	UMI77 UMI-77 UMI 77 CS-1799 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid Acetic acid, 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- 2-[4-[(4-Bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid UMI-77
CAS	518303-20-3

Molecular Formula	C18H14BrNO5S2
Molar Mass	468.34
Density	1.79±0.1 g/cm3(Predicted)
Boling Point	661.2±65.0 °C(Predicted)
Solubility	DMSO: ≥ 28 mg/mL
pKa	2.41±0.30(Predicted)
Storage Condition	-20℃
In vitro study	UMI-77 effectively interferes with BL-Noxa and cell Mcl-1 interactions, as well as Mcl-1/Bax protein-protein interactions. UMI-77 inhibited the growth of pancreatic cancer cells with IC50 values of 3.4,4.4,12.5,16.1, 5.5, and μm for BxPC-3,Panc-1,MiaPaCa-2,AsPC-1, and Capan-2 cells, respectively. UMI-77 induces apoptosis of pancreatic cancer cells by activating the intrinsic apoptotic pathway and/or Bax conformational changes.
In vivo study	In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg I. v.) exhibited a single dose of anti-tumor activity without damaging normal tissue at all.

Last Update：2024-01-02 23:10:35

biological activity	UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing higher selectivity than other members of the Bcl-2 family.
in vitro studies	UMI-77 effectively interfere with the interaction between BL-Noxa and cell Mcl-1, as well as Mcl-1/Bax protein-protein interaction. UMI-77 inhibit the growth of pancreatic cancer cells, the IC50 for BxPC-3,Panc-1,MiaPaCa-2,AsPC-1 and Capan-2 cells is 3.4,4.4,12.5,16.1, and 5.5 μM respectively. UMI-77 induce apoptosis of pancreatic cancer cells by activating the inherent apoptosis pathway and/or Bax conformational changes.
in vivo study	in BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg I. v.) showed single dose anti-tumor activity without damaging normal tissues at all.

Last Update：2024-04-09 20:52:54

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CAS: 518303-20-3
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Product Name: UMI-77 Visit Supplier Webpage Request for quotation
CAS: 518303-20-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid Request for Quotation