2-(1-Piperazinyl) phenol

2-(1-Piperazinyl) phenol - Names and Identifiers

Name	N-(2-Hydroxyphenyl)piperazine
Synonyms	RARECHEM AH CK 0117 2-(1-PIPERAZINO)PHENOL LABOTEST-BB LT01596124 2-piperazin-1-ylphenol 2-(1-Piperazino)phenol o-(1-piperazinyl)phenol 2-(1-Piperazinyl) phenol 2-(piperazin-1-yl)phenol 1-(2-Hydroxyphenyl)piperazine N-(2-Hydroxyphenyl)piperazine 1-(2-HYDROXYPHENYL)PIPERAZINE N-(2-HYDROXYPHENYL)PIPERAZINE 4-(2-hydroxyphenyl)piperazin-1-ium
CAS	1011-17-2
EINECS	213-782-5
InChI	InChI=1/C10H14N2O/c13-10-4-2-1-3-9(10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2/p+1

2-(1-Piperazinyl) phenol - Physico-chemical Properties

Molecular Formula	C10H14N2O
Molar Mass	178.23
Density	1.141
Melting Point	125-129°C
Boling Point	328.2±27.0 °C(Predicted)
Flash Point	152.3°C
Vapor Presure	0.000101mmHg at 25°C
Appearance	White to Brown Powder
BRN	10646
pKa	11.25±0.35(Predicted)
Storage Condition	Room Temprature
MDL	MFCD00190246

2-(1-Piperazinyl) phenol - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
HS Code	29339900
Hazard Note	Irritant
Hazard Class	8
Packing Group	III

2-(1-Piperazinyl) phenol - Introduction

N-(2-Hydroxyphenyl) piperazine is an organic compound with the chemical formula C≡H≡N≡O. It is a white or yellowish crystal with an aromatic odor similar to a benzene ring.

N-(2-hydroxyphenyl) piperazine is mainly used as a pharmaceutical intermediate. It is an important raw material for many drugs, especially used in the synthesis of alpha blockers, antidepressants and antipsychotics. In addition, it is also used in areas such as synthetic dyes and general-purpose solvents.

The method for preparing N-(2-hydroxyphenyl) piperazine can generally be obtained by the reaction of phenol and piperazine. The reaction is usually carried out under alkaline conditions, and the reaction system is heated at an appropriate temperature to synthesize the target product. The specific reaction conditions can be adjusted according to actual needs.

Regarding safety information, N-(2-hydroxyphenyl) piperazine is considered relatively safe under general conditions of use. However, it is still a potentially dangerous compound. During use, appropriate protective measures should be taken, including wearing protective gloves, goggles and protective masks. At the same time, direct contact with skin, eyes and clothing should be avoided, and good ventilation conditions should be maintained. During storage and handling, the compound should be stored separately from oxidants, acids and flammable substances, avoiding fire and high temperatures. In case of accidental splashing or inhalation, take appropriate first aid measures and seek medical attention immediately. Before using N-(2-hydroxyphenyl) piperazine or conducting experiments, it is recommended to refer to and follow relevant safety procedures and guidelines in detail.

Last Update：2024-04-09 21:11:58