2-(2-甲酰氨基噻唑-4-基)乙醛酸乙酯

2-(2-甲酰氨基噻唑-4-基)乙醛酸乙酯 - Names and Identifiers

Name	ethyl 2-formamido-α-oxothiazol-4-acetate
Synonyms	EFTG LABOTEST-BB LT00441209 ethyl 2-formamido-α-oxothiazol-4-acetate ETHYL 2-(FORMYLAMINO)-4-THIAZOLEGLYOXYLATE ETHYL 2-(FORMYLAMINO)THIAZOL-4-YLGLYOXYLATE ETHYL 2-(2-FORMYLAMINOTHIAZOL-4-YL) GLYOXYLATE Ethyl 2-(2-formylaminothiazol-4-yl) glyoxylate ethyl 2-(2-formamidothiazol-4-yl)-2-oxo-acetate ETHYL 2-(2-FORMAMIDO-1,3-THIAZOL-4-YL)-2-OXO-ACETATE ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE Ethyl 2-(2-Formylamino-1,3-Thiazol-4-Yl)-2-Oxoacetate ETHYL-2-(2-FORMYLAMINO-4-THIAZOLE-4-YL)-1-OXY ACETATE (2-FORMYLAMINOTHIAZOL-4-YL)-OXO-ACETIC ACID ETHYL ESTER
CAS	64987-03-7
EINECS	265-299-4
InChI	InChI=1/C8H8N2O4S/c1-2-14-7(13)6(12)5-3-15-8(10-5)9-4-11/h3-4H,2H2,1H3,(H,9,10,11)

2-(2-甲酰氨基噻唑-4-基)乙醛酸乙酯 - Physico-chemical Properties

Molecular Formula	C8H8N2O4S
Molar Mass	228.23
Density	1.5150 (rough estimate)
Melting Point	232-234 °C
Boling Point	381.3±34.0 °C(Predicted)
Flash Point	184.412°C
Solubility	Chloroform (Slightly, Heated), DMSO (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Light Yellow
pKa	8.11±0.70(Predicted)
Storage Condition	2-8°C
Refractive Index	1.5690 (estimate)

2-(2-甲酰氨基噻唑-4-基)乙醛酸乙酯 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
HS Code	29341000

2-(2-甲酰氨基噻唑-4-基)乙醛酸乙酯 - Reference Information

Use

ethylaminothiazole can be used as an intermediate in organic synthesis, in laboratory research and development, and in chemical and pharmaceutical synthesis.

preparation

ethylene acetate tetrahydrate (120g), acetic acid (1000 mL) and acetic anhydride (100 ml) the mixture was stirred in an oil bath heated to 130 °c to 135 °c for 20 minutes, and potassium permanganate (20g) was added to the mixture in 5 minutes with stirring at 105 °c to 110 °c, the mixture was then further stirred at 130 °c to 135 °c for 30 minutes. The mixture was cooled to room temperature, and ethyl 2-(2-formylaminothiazol-4-yl) acetate (53.5g) was added to the mixture. The mixture was then stirred for 15 hours at a rate of 6000ml at 38 °c to 40 °c with introduction of air. Every minute. After the reaction, the precipitate was collected by filtration. The precipitate was washed successively with acetic acid and water and then dried to give ethyl 2-(2-formylaminothiazol-4-yl) glyoxylate (ethylaminothiazole, 41.5g), melting point 232-233 °c (decomposition).

Last Update：2024-04-10 22:29:15