2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid - Names and Identifiers
2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid - Introduction
2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid is an organic compound with the chemical formula C8H5BrF2O2.
Nature:
-Appearance: White crystalline solid
-Melting point: 110-113 ° C
-Boiling point: 273 ° C
-Density: 1.834g/cm³
-Solubility: Soluble in organic solvents such as ethanol and chloroform
Use:
- 2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid can be used as an important intermediate in organic synthesis. It has certain application value in drug synthesis and pesticide synthesis.
Method:
2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid can be prepared by the following steps:
1.2-(2-bromo-5-fluorophenyl)-acetonitrile was obtained by reacting 2-fluorophenylacetonitrile with phenylmagnesium bromide.
2.2. Reaction of 2-(2-bromo-5-fluorophenyl)-acetonitrile with fluoroformic acid to give 2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid.
Safety Information:
- 2-(2-bromo-5-fluorophenyl)-2,2-difluoroacetic acid is relatively stable under normal temperature and pressure, but it may decompose and produce harmful substances at high temperature.
-Use should wear appropriate protective equipment to avoid direct contact with skin and eyes.
-Avoid inhaling its dust or vapor, and operate in a well-ventilated environment.
-Please store and handle the compound in the prescribed manner and follow the relevant safety procedures.
Last Update：2024-04-09 02:00:51