2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid

2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid - Names and Identifiers

Name	2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid
Synonyms	2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Benzeneacetic acid, 4-(1,1-dimethylethyl)-α,α-dimethyl- Benzeneacetic acid, 4-(1,1-dimethylethyl)-a,a-dimethyl-
CAS	93748-14-2

2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid - Physico-chemical Properties

Molecular Formula	C14H20O2
Molar Mass	220.3074
Density	1.013±0.06 g/cm3(Predicted)
Boling Point	323.5±11.0 °C(Predicted)
pKa	4.50±0.10(Predicted)
Storage Condition	2-8°C

2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid - Introduction

2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid is an organic compound with the chemical formula C14H20O2. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: White crystalline solid
-Melting point: 107-110 ° C
-Boiling point: 340 ° C (decomposition)
-Soluble: Soluble in chloroform, carbon disulfide, ether and benzene, almost insoluble in water.

Use:
- 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid can be used as a pharmaceutical intermediate for the synthesis of drugs and other biologically active compounds.

Method:
The preparation method of 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid is as follows:
1. First, 2-(4-(tert-butyl) phenyl) was obtained by reacting p-tert-butylbromobenzene (4-tert-Butyl-bromobenzene) and propylmagnesium bromide (2-Bromo-propylmagnesium bromide) under the catalysis of palladium iodide (PdI2) or nickel iodide (Ni2). -2-Methyl propane.
2. Then, under basic conditions, 2-(4-(tert-butyl) phenyl)-2-methylpropane is reacted with carbon dioxide to give 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid.

Safety Information:
- 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid is an organic compound and should be stored properly and avoid contact with strong oxidants, acids or bases.
-During use or preparation, appropriate protective measures need to be taken, such as the use of protective gloves and goggles.
-Avoid inhalation, ingestion or contact with skin and eyes.
-If you are exposed or unwell, you should seek medical assistance immediately and provide the doctor with the safety data sheet of the compound.

Last Update：2024-04-09 21:01:54