2-(7-amino-2-oxo-chromen-4-yl)acetic acid

2-(7-amino-2-oxo-chromen-4-yl)acetic acid - Names and Identifiers

Name	7-Amino-4-carboxymethylcoumarin
Synonyms	O-(5-bromoethyl)hydroxylamine 7-Amino-4-carboxymethylcoumarin 7-Amino-4-carboxymethyl coumarin 2-(7-Amino-2-oxo-2H-chromen-4-yl) 2-(7-amino-2-oxo-chromen-4-yl)acetic acid (7-Amino-2-oxo-2H-chromen-4-yl)acetic acid (7-Amino-2-oxo-2H-chromen-4-yl)-aceticacid 2-(7-AMino-2-oxo-2H-chroMen-4-yl)acetic acid 2H-1-benzopyran-4-acetic acid, 7-amino-2-oxo- 2H-1-Benzopyran-4-acetic acid, 7-amino-2-oxo-
CAS	85157-21-7
InChI	InChI=1/C11H9NO4/c12-7-1-2-8-6(3-10(13)14)4-11(15)16-9(8)5-7/h1-2,4-5H,3,12H2,(H,13,14)

2-(7-amino-2-oxo-chromen-4-yl)acetic acid - Physico-chemical Properties

Molecular Formula	C11H9NO4
Molar Mass	219.19
Density	1.465±0.06 g/cm3(Predicted)
Melting Point	181-183°C
Boling Point	521.3±50.0 °C(Predicted)
Flash Point	269.052°C
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Off-White to Yellow
pKa	4.27±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.655

2-(7-amino-2-oxo-chromen-4-yl)acetic acid - Reference Information

Use

7-amino-4-carboxymethylcoumarin also known as 7-aminocoumarin -4-acetic acid, it can be used as chemical and pharmaceutical intermediates.

preparation

a 2L round-bottom flask equipped with a condenser was charged with 7-N-(ethoxycarbonyl) aminocoumarin-4-acetic acid (101G, 0.345mol),NaOH(138g,3.45mol) and H2O (ml). The reaction mixture was stirred under reflux for 16 hours. After cooling to room temperature, the pH of the reaction mixture was adjusted to 2 by dropwise addition of H2SO4. The resulting yellow precipitate formed was collected by filtration to give 64.3g(85%) of 5 as a bulky yellow powder. The product was sufficiently pure by NMR analysis. Yield 64.3g,85%.

Last Update：2024-04-10 22:29:15