2-(Methylsulphonyl)acetonitrile
Methylsulfonylacetonitrile
CAS: 2274-42-2
Molecular Formula: C3H5NO2S
2-(Methylsulphonyl)acetonitrile - Names and Identifiers
| Name | Methylsulfonylacetonitrile |
| Synonyms | mesylacetonitrile Methylsufonylacetonitrile Methylsulfonylacetonitrile Methylsulphonylacetonitrile Methanesulfonylacetonitrile 2-(METHYLSULFONYL)ACETONITRILE 2-(Methylsulphonyl)acetonitrile |
| CAS | 2274-42-2 |
| EINECS | 218-888-5 |
| InChI | InChI=1/C3H5NO2S/c1-7(5,6)3-2-4/h3H2,1H3 |
2-(Methylsulphonyl)acetonitrile - Physico-chemical Properties
| Molecular Formula | C3H5NO2S |
| Molar Mass | 119.14 |
| Density | 1.288±0.06 g/cm3(Predicted) |
| Melting Point | 81-84°C(lit.) |
| Boling Point | 360.6±25.0 °C(Predicted) |
| Flash Point | 171.9°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 2.2E-05mmHg at 25°C |
| Appearance | Powder or Crystalline Powder |
| Color | White to off-white |
| BRN | 969929 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.446 |
| MDL | MFCD00014743 |
2-(Methylsulphonyl)acetonitrile - Risk and Safety
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3439 6.1/PG 3 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| Packing Group | III |
2-(Methylsulphonyl)acetonitrile - Introduction
Methylsulfonylacetonitril, chemical formula CH3SO2CN, is an important organic compound. The following is a description of the nature, use, formulation and safety information of Methylsulfonylacetonitrile:
Nature:
-Appearance: colorless liquid;
-Melting point:-29 ° C;
-Boiling Point: 195-200 ° C;
-density: 1.258g/cm³;
-Solubility: Soluble in water, ether and most organic solvents;
-Stability: Stable, but avoid contact with strong oxidants.
Use:
Methylsulfonylacetonitrile has many applications in organic synthesis:
-as a reagent: for sulfonylation reaction, nitrile reaction and nucleophilic substitution reaction;
-As an intermediate: used to prepare organic synthetic compounds such as drugs and pesticides.
Method:
Generally, the preparation of Methylsulfonylacetonitrile can be carried out by the following steps:
1. Reacting methanesulfonyl chloride (CH3SO2Cl) with acetonitrile (CH3CN) in the presence of a base;
2. The reaction mixture was washed with water and purified by distillation to obtain Methylsulfonylacetonitrile.
Safety Information:
- Methylsulfonylacetonitrile is irritating and corrosive, and should avoid contact with skin, eyes and respiratory tract;
-use should wear appropriate protective equipment, such as gloves, safety glasses and protective masks;
-Store away from ignition and oxidizing agents;
-Disposal of scrap in accordance with local regulations.
Nature:
-Appearance: colorless liquid;
-Melting point:-29 ° C;
-Boiling Point: 195-200 ° C;
-density: 1.258g/cm³;
-Solubility: Soluble in water, ether and most organic solvents;
-Stability: Stable, but avoid contact with strong oxidants.
Use:
Methylsulfonylacetonitrile has many applications in organic synthesis:
-as a reagent: for sulfonylation reaction, nitrile reaction and nucleophilic substitution reaction;
-As an intermediate: used to prepare organic synthetic compounds such as drugs and pesticides.
Method:
Generally, the preparation of Methylsulfonylacetonitrile can be carried out by the following steps:
1. Reacting methanesulfonyl chloride (CH3SO2Cl) with acetonitrile (CH3CN) in the presence of a base;
2. The reaction mixture was washed with water and purified by distillation to obtain Methylsulfonylacetonitrile.
Safety Information:
- Methylsulfonylacetonitrile is irritating and corrosive, and should avoid contact with skin, eyes and respiratory tract;
-use should wear appropriate protective equipment, such as gloves, safety glasses and protective masks;
-Store away from ignition and oxidizing agents;
-Disposal of scrap in accordance with local regulations.
Last Update：2024-04-09 02:00:44
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