2-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE
2-(trifluoromethoxy)benzene sulfonyl chloride
CAS: 103008-51-1
Molecular Formula: C7H4ClF3O3S
2-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE - Names and Identifiers
2-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE - Physico-chemical Properties
| Molecular Formula | C7H4ClF3O3S |
| Molar Mass | 260.62 |
| Density | 1.565±0.06 g/cm3(Predicted) |
| Melting Point | 27-31 °C (lit.) |
| Boling Point | 75-77 °C/1 mmHg (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.024mmHg at 25°C |
| BRN | 8482182 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.4825 |
2-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | 34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S39 - Wear eye / face protection. S37 - Wear suitable gloves. S36 - Wear suitable protective clothing. |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| HS Code | 29189900 |
| Hazard Note | Corrosive |
| Hazard Class | 8 |
| Packing Group | II |
2-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE - Reference Information
| Application | 2-(trifluoromethoxy) benzenesulfonyl chloride can be used to produce 2-(trifluoromethoxy) benzenesulfonamide products. 2-(trifluoromethoxy) benzenesulfonamide is a very important organic intermediate. Currently, it is mainly used to produce 2-(trifluoromethoxy) benzenesulfonyl isocyanate. It is an important raw material for the production of sulfonylurea drugs. |
| preparation | ① preparation of 2-(trifluoromethoxy) aniline hydrochloride: in a 1000mL four-mouth bottle, 200g(1.92mol) hydrochloric acid, 100g(0.565 mol) o-amino (trifluoromethoxy) benzene and 80g water are sequentially added at room temperature, stirred for 1h, and the reaction temperature is controlled at 0~30 ℃, 380g of salt-forming reaction solution containing 2-(trifluoromethoxy) aniline hydrochloride was obtained. (2) Preparation of 2-(trifluoromethoxy) benzene diazonium salt: in the stirring state, 120g(0.579mol) of sodium nitrite aqueous solution is added dropwise to the 380g salt-forming reaction solution obtained in step (1), the reaction temperature is controlled at -20~5 ℃, the dropwise addition is completed for 1h, and the temperature is kept for 1h to obtain 500g of diazotization reaction solution containing 2-(trifluoromethoxy) benzene diazonium salt. ③ preparation of 2-(trifluoromethoxy) benzenesulfonyl chloride: 400g(3.84mol) hydrochloric acid, 10g(0.0587mol) copper chloride and 80.0g(0.769mol) sodium bisulfite are added into a 2000mL four-mouth bottle as primer in sequence. in a stirring state, 500g of diazotization reaction solution obtained in step ② is added dropwise to the primer at -20~5 ℃, and the dropwise addition is completed for 5 hours, keep the temperature for 1h, divide the layer at rest, divide the oil layer, add 400g of water, stir for 0.5h, divide the oil layer at rest for 0.5h, and obtain 142g (content 88%)2-(trifluoromethoxy) benzenesulfonyl chloride with 84.9% yield. |
Last Update：2024-04-09 21:04:16
