2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID
2-Amino-5-Chloro-3-Methylbenzoic Acid
CAS: 20776-67-4
Molecular Formula: C8H8ClNO2
2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID - Names and Identifiers
| Name | 2-Amino-5-Chloro-3-Methylbenzoic Acid |
| Synonyms | 3-METHYL-5-CHLORO-ANTHRANILIC ACID 2-Amino-5-chloro-3-methylbenzoicaci 2-Amino-5-chloro-3-Methylbenzoicacid 2-aMino-3-Methyl-5-chlorobenzoic acid 2-Amino-5-Chloro-3-Methylbenzoic Acid 2-amino-3-methyl-5-chlorobenzoic acid 2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID 2-Amino-5-Chloro-3-Methyl Benzoic Acid BENZOIC ACID, 2-AMINO-5-CHLORO-3-METHYL- 2-aMino-3-Methyl-5-chlorobenzoic acid (2-aMino-5-chloro-3-Methylbenzoate) |
| CAS | 20776-67-4 |
| EINECS | 629-058-0 |
| InChI | InChI=1/C8H8ClNO2/c1-4-2-5(9)3-6(7(4)10)8(11)12/h2-3H,10H2,1H3,(H,11,12) |
| InChIKey | KOPXCQUAFDWYOE-UHFFFAOYSA-N |
2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID - Physico-chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molar Mass | 185.61 |
| Density | 1.401±0.06 g/cm3(Predicted) |
| Melting Point | 239-243 °C (lit.) |
| Boling Point | 348.4±42.0 °C(Predicted) |
| Flash Point | 164.481°C |
| Solubility | very slightly in Methanol |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Light yellow to Light red |
| pKa | 4?+-.0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.63 |
| MDL | MFCD02358895 |
2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29224999 |
2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID - Reference Information
| introduction | 2-amino -5-chloro -3-methylbenzoic acid has a melting point of 239 to 243 degrees, a density prediction of 1.4, and a solid powder appearance under normal temperature and pressure. it is a common intermediate in organic synthesis and pharmaceutical chemistry. |
| Use | 2-amino-5-chloro-3-methylbenzoic acid is a common organic synthesis intermediate. The main use is to use the benzene ring The chlorine atom is transformed into the molecular structure of the target. For example, the chlorine atom can be coupled by Suzuki, introducing an aromatic ring or alkyl chain; the carboxyl group on the benzene ring can be easily converted into ester group, hydroxyl group, amide, Webamide and so on. The amino group on the benzene ring can be converted into other active functional groups such as halogen atoms through diazotization reaction; through the selective control and coordination of these reactions, the synthesis of 1,2, 3,5-Tetrasubstituted benzene derivatives can be quickly prepared. |
| Synthesis method | For the synthesis of 2-amino -5-chloro -3-methylbenzoic acid, the synthesis method obtained by literature search is from 2-amino -3-Starting from methylbenzoic acid, it reacts with N-chlorosuccinimide under the condition of DMF as a solvent to obtain a chlorine product at the para-position of the amino group, the reaction has good regioselectivity, which may be due to the para-location reactivity caused by the strong electron donating ability of the amino group. It is worth noting that this route needs to be heated to achieve a satisfactory reaction effect. |
Last Update：2024-04-09 21:01:54
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View History
2-AMINO-5-CHLORO-3-METHYLBENZOIC ACID
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[(1H-苯并三唑-1-基)甲基]三苯基氯化鏻
3-(2-羟基-3-硝基-5-氯基)苯基联苯甲酸
三甲基甲基硫酸硫
3-溴丙基苄基醚
2-乙基-3-羟基-6-甲基吡啶琥珀盐酸
C.I. Pigment Red 81
2-羟基-3-硝基6-甲基吡啶
FMOC-3-氨基-3-苯基丙酸
2,4,6-Cycloheptatrien-1-one, 3,7-bis(bromomethyl)-2-hydroxy-