2-Acetamidopyridine-5-boronic acid pinacol ester

2-Acetamidopyridine-5-boronic acid pinacol ester - Names and Identifiers

Name	N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide
Synonyms	2-Acetamidopyridine-5-boronic acid pinacol ester 6-Acetamidopyridine-3-boronic acid pinacol ester [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]acetamide N-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]acetamide N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide N-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-acetamide 2-(Acetylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 6-(Acetylamino)pyridine-3-boronic acid, pinacol ester 6-(Acetylamino)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 6-(Acetylamino)pyridine-3-boronic acid, pinacol ester
CAS	904326-87-0
EINECS	200-528-9
InChI	InChI=1/C13H19BN2O3/c1-9(17)16-11-7-6-10(8-15-11)14-18-12(2,3)13(4,5)19-14/h6-8H,1-5H3,(H,15,16,17)
InChIKey	YCWPTBAHVWJMEY-UHFFFAOYSA-N

2-Acetamidopyridine-5-boronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C13H19BN2O3
Molar Mass	262.11
Density	1.11±0.1 g/cm3(Predicted)
Melting Point	130-134 °C
Boling Point	444.4±30.0 °C(Predicted)
Flash Point	222.5°C
Vapor Presure	4.31E-08mmHg at 25°C
pKa	13.95±0.70(Predicted)
Storage Condition	2-8°C
Refractive Index	1.509

2-Acetamidopyridine-5-boronic acid pinacol ester - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

2-Acetamidopyridine-5-boronic acid pinacol ester - Introduction

N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide is an organic compound with the chemical formula C14H20BNO3. The following is a description of the properties, uses, preparation and safety information of the compound:

1. nature:
-Appearance: White crystalline solid;
-Solubility: Soluble in some organic solvents, such as dichloromethane;
-Melting point: about 125-135°C.

2. use:
-As an intermediate in organic synthesis, it can be used to synthesize other organic compounds;
-It can be used in the field of drug development and preparation, and used to synthesize pharmaceutically active molecules.

3. preparation method:
N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide can be prepared by the following steps:
-at a lower temperature, 5-pyridinecarboxaldehyde is reacted with 4,4,5,5-tetramethyl-1,3, 2-dioxaborole-2-glutanol to generate 2-(5-Pyridyl) acetaldehyde, which is then reacted with aminoacetic acid to obtain N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl] acetamide.) pyridin-2-yl.

4. Safety Information:
-the compound does not pose a significant health hazard under reasonable use;
-but as an organic synthesis reagent, need to comply with the safety procedures, such as wearing protective gloves, glasses, etc;
-Avoid inhalation, ingestion or skin contact during operation. If contact occurs, rinse immediately with water and seek medical help.

Last Update：2024-04-09 15:18:00