2-Amino-2,3-dimethylbutyronitrile
2-Amino-2,3-dimethylbutyronitrile
CAS: 13893-53-3
Molecular Formula: C6H12N2
2-Amino-2,3-dimethylbutyronitrile - Names and Identifiers
2-Amino-2,3-dimethylbutyronitrile - Physico-chemical Properties
| Molecular Formula | C6H12N2 |
| Molar Mass | 112.17 |
| Density | 0.896±0.06 g/cm3(Predicted) |
| Boling Point | 43 °C |
| Flash Point | 58.8°C |
| Solubility | Chloroform, Methanol (Slightly) |
| Vapor Presure | 8.98-101430Pa at 20-165.5℃ |
| Appearance | Oil |
| Color | Light Yellow |
| pKa | 5.18±0.25(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Physical and Chemical Properties | This product is colorless liquid, alkaline, B. p.85 ~ 87 ℃/0.94 kPa,n25D 1.4333, slightly soluble in water, miscible with ether, ethanol and other organic solvents. |
2-Amino-2,3-dimethylbutyronitrile - Reference Information
| LogP | 0.7 at 23℃ and pH6.1-10.5 |
| dissociation constant | 5 at 25 ℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | 2-amino -2, 3-dimethylbutyronitrile is used by Rhodococcus cyanogenes for the biosynthesis of 2-amino -2, 3-dimethylbutyramide, which is an important intermediate for the synthesis of powerful imidazoline herbicides. In addition, it is also used for the preparation of new chiral ligands. 2-amino -2, 3-dimethylbutyronitrile is an intermediate for the synthesis of Imidazolinone herbicides, such as imidazolidinic acid, imidazolinic acid, imidazolinic acid, imidazolinic acid and methylimidazolinone. |
| production method | the preparation method is to add sodium cyanide, water and concentrated ammonia water in the reaction bottle, and stir at room temperature, sodium cyanide is completely dissolved, then NH4Cl and phase transfer catalyst benzyl triethylammonium chloride are added, methyl isopropyl ketone is added dropwise under stirring, and the dropping speed is controlled so that the liquid temperature does not exceed 30 ℃, and the mixture is stirred for 4-6h at room temperature after addition, the organic phase was separated, and the aqueous phase was extracted twice with dichloromethane. The organic phases were combined and dried over anhydrous sodium sulfate, A small amount of unreacted methyl isopropyl ketone was distilled off, and a fraction of 85-87 ° C./0.94 kPa was collected by distillation under reduced pressure as a finished product. |
Last Update：2024-04-09 21:01:54
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CAS: 13893-53-3
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