2-Amino-5-bromonicotonic acid
2-Amino-5-bromonicotinic acid
CAS: 52833-94-0
Molecular Formula: C6H5BrN2O2
2-Amino-5-bromonicotonic acid - Names and Identifiers
2-Amino-5-bromonicotonic acid - Physico-chemical Properties
| Molecular Formula | C6H5BrN2O2 |
| Molar Mass | 217.02 |
| Density | 1.909 |
| Melting Point | 253-255°C |
| Boling Point | 350.4±42.0 °C(Predicted) |
| Flash Point | 165.686°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| pKa | 2.55±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.5150 (estimate) |
| MDL | MFCD01860227 |
2-Amino-5-bromonicotonic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN2811 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
2-Amino-5-bromonicotonic acid - Reference Information
| Uses | 2-amino-5-bromonicotinic acid is an organic intermediate, which can be prepared from 2-aminonicotinic acid bromination. It has been reported that 2-amino-5-bromonicotinic acid can be used to prepare 6-pyrazole-substituted quinazoline compounds and their derivatives. These compounds have high tyrosine kinase inhibitory activity and strong inhibitory activity on human breast cancer cells and lung adenocarcinoma cells. |
| Preparation method | 2-amino-5-bromonicotinic acid is an organic intermediate, which can be prepared by 2-aminonicotinic acid bromination. |
| preparation | in a 500mL three-mouth bottle equipped with a stirrer and a reflux condenser tube, add 20.7g(0.15mol) of 2-amino nicotinic acid and 80mL of acetic acid, stir at room temperature, drop 40mL of acetic acid and 4.1mL of bromine (0.08mol) mixed solution with a constant pressure dropping funnel, and continue stirring for 4-5 hours after dropping. Filtration, washing with acetic acid, drying, heating and reflux of solids with methanol 100mL for 10min, placing at room temperature, filtering and drying. 31.2g of white solid 2-amino -5-bromonicotinic acid was obtained with 96% yield. 1H NMR(400MHz,DMSO-d6)δ12.72(s,1H),9.05(d,J=2.4Hz,1H),8.63(d,J=2.4Hz,1H),8.36(s,1H). MS:m/z(ESI )228.3[M H]. |
Last Update：2024-04-09 21:00:56
Supplier List
Product Name: 2-Amino-5-bromonicotinic acid Visit Supplier Webpage Request for quotation
CAS: 52833-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 52833-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 2-Amino-5-bromonicotinic acid Visit Supplier Webpage Request for quotation
CAS: 52833-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 52833-94-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History