2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester

Name	HA14-1
Synonyms	CS-392 HA14-1 ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
CAS	65673-63-4

Molecular Formula	C17H17BrN2O5
Molar Mass	409.23
Density	1.480
Melting Point	105 °C
Solubility	DMSO: 26mg/mL
Appearance	powder
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
In vitro study	HA14-1 is a Bcl-2 small non-peptide ligand with a molecular weight of 409 and an IC50 of about 9 μm. HA14-1 induces apoptosis in HL-60 cells by activating caspase in a dose-dependent manner. HA14-1 acted on follicular lymphoma cell lines HF1A3, HF4.9, and HF28RA, and was cytotoxic with LC50 of 4.5 μm, 12.6 μm, and 8.1 μm, respectively. HA14-1 induced apoptosis of HF1A3, HF4.9 and HF28RA cells by caspase and ROS.
In vivo study	HA14-1(400 nM) treatment of immunodeficient mice did not have any significant effect on glioblastoma growth. However, HA14-1(400 nM) promoted the effect of the DNA damaging agent Etoposide (2.5 mg/kg) on glioblastoma growth in vivo.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29322090

Last Update：2024-01-02 23:10:35

biological activity	HA14-1 is a Bcl-2 surface pocket non-peptide ligand with an IC50 of about 9 μm.
Target	Value
Bcl-2	9 μM

Last Update：2024-04-10 22:29:15

Spot supply

Product Name: HA14-1 Visit Supplier Webpage Request for quotation
CAS: 65673-63-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Spot supply

Product Name: HA14-1 Visit Supplier Webpage Request for quotation
CAS: 65673-63-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester Request for Quotation