2-Bromomethylthiophene

Name	THIOPHENE, 2-(BROMOMETHYL)-
Synonyms	2-Bromomethylthiophene THIOPHENE, 2-(BROMOMETHYL)-
CAS	45438-73-1

Overview	The 2-bromomethylthiophene molecule is a five-membered heterocyclic conjugated system, and the unshared electron pair on the sulfur atom increases the electron cloud density on the ring, Enhance the reactivity of ring-forming carbon atoms (especially the 2 and 5 atoms), therefore, thiophene is prone to nitrification, sulfonation, alkylation, acylation and halogenation, and a variety of thiophene heterocyclic compounds are derived.
uses	2-bromomethylthiophene is an important intermediate for the synthesis of various antispasmodic drugs and semi-synthetic antibiotics, and is widely used in the fields of medicine, pesticide, dye, resin and chemical industry.
preparation	in a fully automatic organic synthesizer, a certain amount of thiophene and concentrated hydrobromic acid are added, a cooling system is opened, and dry hydrogen bromide gas is introduced under constant stirring. When the waiting liquid drops to a certain temperature, a certain amount of formaldehyde gas is introduced (formaldehyde gas and hydrogen bromide gas are measured by weighing method). After the reaction is over, extract 3 times with 3 times the volume of anhydrous ether, the combined extract is washed with distilled water, and then dried with anhydrous sodium sulfate. After the ether was recovered, the fraction of 75 ℃/2.27kPa was collected by vacuum distillation to obtain a colorless oily liquid, and the final product was verified by gas-mass spectrometry.

Last Update：2024-04-10 22:29:15

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CAS: 45438-73-1
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2-Bromomethylthiophene

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