2-Chloro-4-(trifluoromethoxy)phenol

2-Chloro-4-(trifluoromethoxy)phenol - Names and Identifiers

Name	2-Chloro-4-(trifluoromethoxy)phenol
Synonyms	2-CHLORO-4-TRIFLUOROMETHOXYPHENOL 2-Chloro-4-(trifluoromethoxy)phenol 4-(trifluoromethoxy)-2-chlorophenol Phenol, 2-chloro-4-(trifluoromethoxy)-
CAS	70783-75-4
InChI	InChI=1/C7H4ClF3O2/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3,12H

2-Chloro-4-(trifluoromethoxy)phenol - Physico-chemical Properties

Molecular Formula	C7H4ClF3O2
Molar Mass	212.55
Density	1.515±0.06 g/cm3(Predicted)
Boling Point	67-70 °C(Press: 18 Torr)
Flash Point	75.1°C
Vapor Presure	0.228mmHg at 25°C
pKa	7.88±0.18(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.484

2-Chloro-4-(trifluoromethoxy)phenol - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

2-Chloro-4-(trifluoromethoxy)phenol - Introduction

2-Chloro-4-(trifluoromethoxy)phenol is an organic compound with the chemical formula C7H4ClF3O2.

Nature:
2-Chloro-4-(trifluoromethoxy)phenol is a white crystalline solid. It has strong acidity and can be dissolved in organic solvents. The compound has a large water solubility and vapor pressure.

Use:
Due to its acidic and active groups, 2-Chloro-4-(trifluoromethoxy)phenol is widely used as an intermediate in the pharmaceutical, pesticide and dye industries. It can also be used as an antiseptic, disinfectant and mildewproofing agent.

Preparation Method:
2-Chloro-4-(trifluoromethoxy)phenol can be obtained by reacting 2-chloro-4-nitrophenol with trifluoromethanol. First, 2-chloro-4-nitrophenol and trifluoromethane are reacted under alkaline conditions to obtain 2-chloro-4-nitro-5-(trifluoromethoxy) phenol, which is then reduced to obtain the target product.

Safety Information:
2-Chloro-4-(trifluoromethoxy)phenol has several safety risks. It may be irritating to the eyes and skin and may be toxic to the respiratory and digestive systems. Therefore, when using and handling the compound, appropriate protective measures should be taken, including wearing chemical protective gloves and goggles, and ensuring that the operation is carried out in a well-ventilated area.

Last Update：2024-04-10 22:29:15